Cardinals vs. Seahawks prediction: Seattle favored to win in NFL Week 10, 2025

The Seattle Seahawks and Arizona Cardinals will meet in Week 10 of the NFL season at Lumen Field on Sunday, starting at 4:05PM ET.

Based on updated simulation results, Dimers' advanced NFL model predicts the Seahawks as the most likely winner of the Cardinals vs. Seahawks game.

This article offers a closer look at Sunday's matchup, including touchdown scorer projections, best bets and player prop picks.

Cardinals vs. Seahawks prediction: Who will win, cover the spread?

Since our Cardinals-Seahawks predictions earlier in the week, we have simulated the result of Sunday's NFL matchup between the Cardinals and Seahawks 10,000 times as part of our NFL predictions coverage.

Our independent predictive model currently gives the Seahawks a 74% chance of beating the Cardinals in Week 10 of the NFL season. Our predicted final score has the Seahawks winning 25-18.

According to our model, the Cardinals (+7.5) have a 54% chance of covering the spread, while the over/under total of 44.5 points has an equal 50-50 chance of hitting.

To see win probabilities for every matchup this week, check out our expert NFL Week 10 straight up picks.

Cardinals vs. Seahawks odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	Cardinals	Seahawks
Spread	+7.5 (-115)	-7.5 (-105)
Moneyline	+285	-325
Total	o44.5 (-105)	u44.5 (-102)

All odds are correct at the time of publication and are subject to change.

Cardinals vs. Seahawks picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Cardinals +7.5	-115
Moneyline	Cardinals	+285
Total	Under 44.5	-102

According to our NFL best bets, the top play to make on this game is Cardinals +7.5 at the spread.

Cardinals vs. Seahawks TD scorers

Who will score a touchdown in Cardinals vs. Seahawks?

According to our list of touchdown scorer predictions for Week 10, Jaxon Smith-Njigba is most likely to score an anytime TD in Cardinals vs. Seahawks.

Our projections give Smith-Njigba a 45.8% chance of scoring a TD at Lumen Field, while the wide receiver is a 10.9% chance of registering the first touchdown the game.

Anytime touchdown scorer predictions

Arizona Cardinals

Player	Anytime TD Probability
Trey McBride (TE)	33.5%
Marvin Harrison (WR)	31.3%
Bam Knight (RB)	27.5%
Emari Demercado (RB)	27.0%
Michael Wilson (WR)	19.3%

Seattle Seahawks

Player	Anytime TD Probability
Jaxon Smith-Njigba (WR)	45.8%
Zach Charbonnet (RB)	40.5%
Kenneth Walker (RB)	35.6%
Rashid Shaheed (WR)	28.2%
AJ Barner (TE)	26.6%

First touchdown scorer predictions

Arizona Cardinals

Player	First TD Probability
Trey McBride (TE)	7.8%
Marvin Harrison (WR)	7.2%
Bam Knight (RB)	6.1%
Emari Demercado (RB)	6.0%
Michael Wilson (WR)	4.1%

Seattle Seahawks

Player	First TD Probability
Jaxon Smith-Njigba (WR)	10.9%
Zach Charbonnet (RB)	9.2%
Kenneth Walker (RB)	7.8%
Rashid Shaheed (WR)	5.9%
AJ Barner (TE)	5.5%

Cardinals vs Seahawks player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Cardinals and Seahawks. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 10 games.

Quarterbacks

Of the starting quarterbacks, the Cardinals' Jacoby Brissett is projected for 235 passing yards. The Seahawks' Sam Darnold is expected to throw for 252 yards.

Player	Proj. Pass Yards
Jacoby Brissett (ARI)	235
Sam Darnold (SEA)	252

Cardinals rushing

Player	Proj. Rush Yards
Emari Demercado	42
Bam Knight	32
Jacoby Brissett	16

Seahawks rushing

Player	Proj. Rush Yards
Kenneth Walker	58
Zach Charbonnet	42
Sam Darnold	8

Cardinals receiving

Player	Proj. Rec. Yards
Trey McBride	64
Marvin Harrison	59
Michael Wilson	34
Zay Jones	20
Bam Knight	15

Seahawks receiving

Player	Proj. Rec. Yards
Jaxon Smith-Njigba	101
Rashid Shaheed	39
Cooper Kupp	33
AJ Barner	30
Elijah Arroyo	23

Cardinals vs. Seahawks game-day updates and essential details

The NFL Week 10 action between the Seahawks and Cardinals at Lumen Field is scheduled to start at 4:05PM ET.

• Who: Arizona Cardinals vs. Seattle Seahawks
• Date: Sunday, November 9, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Lumen Field

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Conclusion

We predict the Seahawks, with a 74% win probability, will likely beat the Cardinals in Week 10 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Seahawks insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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