West Florida vs. Southeast Missouri State prediction favors Southeast Missouri State to win in college football Week 4 [2026]

Using innovative machine learning and data, we have re-simulated the result of West Florida vs. Southeast Missouri State, forming part of our college football predictions coverage.

Our independent predictive model gives Southeast Missouri State a 65.0% chance of beating West Florida. Our predicted final score has Southeast Missouri State winning 29-23. According to our model, West Florida (+6.5) has a 51.1% chance of covering the spread, while the over/under total of 52.5 points has a 50.4% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: West Florida +6.5 (-125) / Southeast Missouri State -6.5 (-105)
• Moneyline: West Florida +170, Southeast Missouri State -195
• Total: Over/Under 52.5 (-111/-111)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southeast Missouri State -6.5 @ -105 via bet365
• Moneyline: Southeast Missouri State @ -195 via DraftKings
• Total: Over 52.5 @ -111 via DraftKings

According to our college football best bets, the top play to make on this game is Southeast Missouri State to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Southeast Missouri State and West Florida at Houck Field is scheduled to start at 7:00 PM ET.

• Who: West Florida vs. Southeast Missouri State
• Date: Saturday, September 26, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Houck Field

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Make the most of Dimers' West Florida vs. Southeast Missouri State predictions by exploring the Bet365 Sportsbook offer below:

Conclusion

We predict Southeast Missouri State, with a 65.0% win probability, will likely beat West Florida in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.