Ole Miss vs. Florida prediction favors Florida to win in college football Week 4 [2026]

Using powerful machine learning and data, we have re-simulated the outcome of Ole Miss vs. Florida, forming part of our college football predictions coverage.

Our leading predictive model currently gives Florida a 61.8% chance of beating Mississippi. Our predicted final score has Florida winning 31-27. According to our model, Florida (-3.5) has a 50.8% chance of covering the spread, while the 58.5-point over/under has a 51.3% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Ole Miss +3.5 (-110) / Florida -3.5 (-104)
• Moneyline: Ole Miss +145, Florida -166
• Total: Over/Under 58.5 (-114/-105)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Florida -3.5 @ -104 via FanDuel
• Moneyline: Florida @ -166 via FanDuel
• Total: Over 58.5 @ -114 via FanDuel

According to our college football best bets, the top play to make on this game is Florida -3.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Florida and Ole Miss at Ben Hill Griffin Stadium is scheduled to start at 3:30 PM ET.

• Who: Mississippi vs. Florida
• Date: Saturday, September 26, 2026
• Time: 3:30 PM ET/12:30PM PT
• Venue: Ben Hill Griffin Stadium

College football Week 4 promos

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Conclusion

We predict Florida, with a 61.8% win probability, will likely beat Mississippi in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.