Illinois vs. Ohio State prediction favors Ohio State to win in college football Week 4 [2026]

Using innovative machine learning and data, we have re-simulated the outcome of Illinois vs. Ohio State, forming part of our college football predictions coverage.

Our famous predictive model gives Ohio State a 98.0% chance of beating Illinois. Our predicted final score has Ohio State winning 40-14. According to our model, Illinois (+27.5) has a 52.6% chance of covering the spread, while the 54.5-point over/under has a 50.1% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Illinois +27.5 (-108) / Ohio State -27.5 (+100)
• Moneyline: Illinois +1650, Ohio State -4000
• Total: Over/Under 54.5 (-110/-105)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Illinois +27.5 @ -108 via BetRivers
• Moneyline: Ohio State @ -4000 via DraftKings
• Total: Under 54.5 @ -105 via FanDuel

According to our college football best bets, the top play to make on this game is Illinois +27.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Ohio State and Illinois at Ohio Stadium is scheduled to commence at 12:00 PM ET.

• Who: Illinois vs. Ohio State
• Date: Saturday, September 26, 2026
• Time: 12:00 PM ET/9:00AM PT
• Venue: Ohio Stadium

College football Week 4 promos

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Conclusion

We predict Ohio State, with a 98.0% win probability, will likely beat Illinois in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.