James Madison vs. Old Dominion prediction favors James Madison to win in college football Week 4 [2026]

Using powerful machine learning and data, we have re-simulated the outcome of James Madison vs. Old Dominion, forming part of our college football predictions coverage.

Our leading predictive model gives James Madison a 65.3% chance of beating Old Dominion. Our predicted final score has James Madison winning 25-19. According to our model, Old Dominion (+6.5) has a 52.5% chance of covering the spread, while the 43.5-point over/under has a 54.5% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: James Madison -6.5 (+100) / Old Dominion +6.5 (-115)
• Moneyline: James Madison -220, Old Dominion +190
• Total: Over/Under 43.5 (-115/-104)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Old Dominion +6.5 @ -115 via FanDuel
• Moneyline: Old Dominion @ +190 via bet365
• Total: Over 43.5 @ -115 via bet365

According to our best college football bets, the top play to make on this game is Over 43.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Old Dominion and James Madison at Kornblau Field at S.B. Ballard Stadium is scheduled to commence at 6:00 PM ET.

• Who: James Madison vs. Old Dominion
• Date: Saturday, September 26, 2026
• Time: 6:00 PM ET/3:00PM PT
• Venue: Kornblau Field at S.B. Ballard Stadium

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Conclusion

We predict James Madison, with a 65.3% win probability, will likely beat Old Dominion in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.