William & Mary vs. Duke prediction favors Duke to win in college football Week 4 [2026]

Using powerful machine learning and data, we have re-simulated the outcome of William & Mary vs. Duke, forming part of our college football predictions coverage.

Our famous predictive model gives Duke a 99.1% chance of beating William & Mary. Our predicted final score has Duke winning 52-9. According to our model, William & Mary (+43.5) has a 51.6% chance of covering the spread, while the 62.5-point over/under has a 50.6% chance of staying under.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: William & Mary +43.5 (-105) / Duke -43.5 (-110)
• Moneyline: William & Mary , Duke

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Under @ -110 via Bet365

According to our college football best bets, the top play to make on this game is William & Mary +43.5.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Duke and William & Mary at Brooks Field at Wallace Wade Stadium is scheduled to start at 3:30 PM ET.

• Who: William & Mary vs. Duke
• Date: Saturday, September 26, 2026
• Time: 3:30 PM ET/12:30PM PT
• Venue: Brooks Field at Wallace Wade Stadium

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Conclusion

We predict Duke, with a 99.1% win probability, will likely beat William & Mary in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.