Northwestern vs. Indiana prediction: Why Indiana is favored to win in college football Week 4 [2026]

Indiana and Northwestern will clash in Week 4 college football action at Memorial Stadium on Friday, with kickoff at 8:00 PM ET.

Dimers' advanced college football model gives Indiana a slight edge with a 94.6% win probability over Northwestern.

This article offers a complete Northwestern vs. Indiana prediction, including an expanded look at the predicted score, best bets and picks.

Northwestern vs. Indiana prediction and odds

Using trusted machine learning and data analysis, we have re-simulated the outcome of Northwestern vs. Indiana, forming part of our college football predictions coverage.

Our famous predictive model currently gives Indiana a 94.6% chance of beating Northwestern. Our predicted final score has Indiana winning 35-14. According to our model, Indiana (-20.5) has a 51.7% chance of covering the spread, while the 49.5-point over/under has a 52.4% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Northwestern +20.5 (-105) / Indiana -20.5 (-106)
• Moneyline: Northwestern +1000, Indiana -1650
• Total: Over/Under 49.5 (-110/-105)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Indiana -20.5 @ -106 via FanDuel
• Moneyline: Indiana @ -1650 via DraftKings
• Total: Over 49.5 @ -110 via bet365

According to our college football best bets, the top play to make on this game is Indiana to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Friday's college football action between Indiana and Northwestern at Memorial Stadium is scheduled to commence at 8:00 PM ET.

• Who: Northwestern vs. Indiana
• Date: Friday, September 25, 2026
• Time: 8:00 PM ET/5:00PM PT
• Venue: Memorial Stadium

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Conclusion

We predict Indiana, with a 94.6% win probability, will likely beat Northwestern in Friday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.