Northwestern vs. Indiana prediction: Why Indiana is favored to win in college football Week 4 [2026]

Using trusted machine learning and data, we have re-simulated the result of Northwestern vs. Indiana, forming part of our college football predictions coverage.

Our famous predictive model currently gives Indiana a 94.4% chance of beating Northwestern. Our predicted final score has Indiana winning 35-14. According to our model, Indiana (-20.5) has a 51.7% chance of covering the spread, while the 49.5-point over/under has a 51.9% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Northwestern +20.5 (-104) / Indiana -20.5 (-110)
• Moneyline: Northwestern +1100, Indiana -1700
• Total: Over/Under 49.5 (-110/-108)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Indiana -20.5 @ -110 via DraftKings
• Moneyline: Indiana @ -1700 via Caesars
• Total: Over 49.5 @ -110 via Caesars

According to our college football best bets, the top play to make on this game is Indiana to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Friday's college football game between Indiana and Northwestern at Memorial Stadium is scheduled to start at 8:00 PM ET.

• Who: Northwestern vs. Indiana
• Date: Friday, September 25, 2026
• Time: 8:00 PM ET/5:00PM PT
• Venue: Memorial Stadium

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Conclusion

We predict Indiana, with a 94.4% win probability, will likely beat Northwestern in Friday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.