Syracuse vs. Virginia prediction favors Virginia to win in college football Week 6 [2026]

Using powerful machine learning and statistical analysis, we have re-simulated the result of Syracuse vs. Virginia, forming part of our college football predictions coverage.

Our famous predictive model currently gives Virginia an 82.3% chance of beating Syracuse. Our predicted final score has Virginia winning 31-19. According to our model, Virginia (-11) has a 53.3% chance of covering the spread, while the over/under total of 49.5 points has a 52.4% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Syracuse +11 (-110) / Virginia -11 (-113)
• Moneyline: Syracuse +380, Virginia -440
• Total: Over/Under 49.5 (-110/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Virginia -11 @ -113 via BetRivers
• Moneyline: Virginia @ -440 via Caesars
• Total: Over 49.5 @ -110 via DraftKings

According to our college football best bets, the top play to make on this game is Virginia to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Virginia and Syracuse at Scott Stadium is scheduled to begin at 7:30 PM ET.

• Who: Syracuse vs. Virginia
• Date: Saturday, October 10, 2026
• Time: 7:30 PM ET/4:30PM PT
• Venue: Scott Stadium

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Conclusion

We predict Virginia, with an 82.3% win probability, will likely beat Syracuse in Saturday's college football matchup.

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This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.