Louisiana-Monroe vs. South Alabama prediction favors South Alabama to win in college football Week 5 [2026]

Using innovative machine learning and statistical analysis, we have re-simulated the result of Louisiana-Monroe vs. South Alabama, forming part of our college football predictions coverage.

Our independent predictive model currently gives South Alabama an 83.1% chance of beating Louisiana-Monroe. Our predicted final score has South Alabama winning 33-22. According to our model, Louisiana-Monroe (+13.5) has a 55.2% chance of covering the spread, while the 56.5-point over/under has a 50.5% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Louisiana-Monroe +13.5 (-108) / South Alabama -13.5 (-110)
• Moneyline: Louisiana-Monroe +480, South Alabama -575
• Total: Over/Under 56.5 (-110/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Louisiana-Monroe +13.5 @ -108 via Caesars
• Moneyline: Louisiana-Monroe @ +480 via BetRivers
• Total: Over 56.5 @ -110 via bet365

According to our college football best bets, the top play to make on this game is Louisiana-Monroe +13.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between South Alabama and Louisiana-Monroe at Hancock Whitney Stadium is scheduled to begin at 7:00 PM ET.

• Who: Louisiana-Monroe vs. South Alabama
• Date: Saturday, October 3, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Hancock Whitney Stadium

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Conclusion

We predict South Alabama, with an 83.1% win probability, will likely beat Louisiana-Monroe in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.