Purdue vs. Illinois prediction: Why Illinois is favored to win in college football Week 5 [2026]

Using powerful machine learning and data, we have re-simulated the outcome of Purdue vs. Illinois, forming part of our college football predictions coverage.

Our independent predictive model currently gives Illinois an 81.2% chance of beating Purdue. Our predicted final score has Illinois winning 36-24. According to our model, Illinois (-9.5) has a 55.5% chance of covering the spread, while the 62.5-point over/under has a 52.8% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Purdue +9.5 (-105) / Illinois -9.5 (-115)
• Moneyline: Purdue +350, Illinois -375
• Total: Over/Under 62.5 (-110/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Illinois -9.5 @ -115 via bet365
• Moneyline: Illinois @ -375 via DraftKings
• Total: Under 62.5 @ -106 via FanDuel

According to our college football best bets, the top play to make on this game is Illinois to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Illinois and Purdue at Gies Memorial Stadium is scheduled to commence at 4:15 PM ET.

• Who: Purdue vs. Illinois
• Date: Saturday, October 3, 2026
• Time: 4:15 PM ET/1:15PM PT
• Venue: Gies Memorial Stadium

College football Week 5 promos

Make the most of Dimers' Purdue vs. Illinois predictions by exploring the Bet365 Sportsbook offer below:

Conclusion

We predict Illinois, with an 81.2% win probability, will likely beat Purdue in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.