Ohio State vs. Iowa prediction: Why Ohio State is favored to win in college football Week 5 [2026]

Using innovative machine learning and data analysis, we have re-simulated the result of Ohio State vs. Iowa, forming part of our college football predictions coverage.

Our independent predictive model currently gives Ohio State an 85.6% chance of defeating Iowa. Our predicted final score has Ohio State winning 30-16. According to our model, Iowa (+14.5) has a 50.8% chance of covering the spread, while the over/under total of 45.5 points has a 53.3% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Ohio State -14.5 (-104) / Iowa +14.5 (-112)
• Moneyline: Ohio State -625, Iowa +490
• Total: Over/Under 45.5 (-105/-107)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Ohio State -14.5 @ -104 via FanDuel
• Moneyline: Ohio State @ -625 via DraftKings
• Total: Over 45.5 @ -105 via FanDuel

According to our best college football bets, the top play to make on this game is Over 45.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Iowa and Ohio State at Kinnick Stadium is scheduled to commence at 3:30 PM ET.

• Who: Ohio State vs. Iowa
• Date: Saturday, October 3, 2026
• Time: 3:30 PM ET/12:30PM PT
• Venue: Kinnick Stadium

College football Week 5 promos

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Conclusion

We predict Ohio State, with an 85.6% win probability, will likely beat Iowa in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.