Holy Cross vs. William & Mary prediction: Why William & Mary is favored to win in college football Week 5 [2026]

Using innovative machine learning and statistical analysis, we have re-simulated the result of Holy Cross vs. William & Mary, forming part of our college football predictions coverage.

Our famous predictive model gives William & Mary a 65.0% chance of beating Holy Cross. Our predicted final score has William & Mary winning 28-23. According to our model, Holy Cross (+6.5) has a 53.8% chance of covering the spread, while the over/under total of 49.5 points has a 53.9% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Holy Cross +6.5 (-110) / William & Mary -6.5 (-110)
• Moneyline: Holy Cross +180, William & Mary -228
• Total: Over/Under 49.5 (-113/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Holy Cross +6.5 @ -110 via DraftKings
• Moneyline: Holy Cross @ +180 via bet365
• Total: Over 49.5 @ -113 via DraftKings

According to our college football best bets, the top play to make on this game is Holy Cross +6.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between William & Mary and Holy Cross at Walter J. Zable Stadium at Cary Field is scheduled to begin at 3:30 PM ET.

• Who: Holy Cross vs. William & Mary
• Date: Saturday, October 3, 2026
• Time: 3:30 PM ET/12:30PM PT
• Venue: Walter J. Zable Stadium at Cary Field

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Conclusion

We predict William & Mary, with a 65.0% win probability, will likely beat Holy Cross in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.