Buffalo vs. Penn State prediction: Why Penn State is favored to win in college football Week 3 [2026]

Penn State and Buffalo will lock horns in Week 3 college football action at West Shore Home Field at Beaver Stadium on Saturday, with kickoff at 12:00 PM ET.

Dimers' advanced college football model projects Penn State as the most likely winner in this Buffalo vs. Penn State prediction.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Buffalo vs. Penn State prediction and odds

Using innovative machine learning and data, we have re-simulated the outcome of Buffalo vs. Penn State, forming part of our college football predictions coverage.

Our leading predictive model currently gives Penn State a 99.4% chance of beating Buffalo. Our predicted final score has Penn State winning 42-6. According to our model, Buffalo (+39.5) has a 59.3% chance of covering the spread, while the 47.5-point over/under has a 55.8% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Buffalo +39.5 (-108) / Penn State -39.5 (-110)
• Moneyline: Buffalo , Penn State

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Over @ -115 via FanDuel

According to our college football best bets, the top play to make on this game is Buffalo +39.5.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Penn State and Buffalo at West Shore Home Field at Beaver Stadium is scheduled to begin at 12:00 PM ET.

• Who: Buffalo vs. Penn State
• Date: Saturday, September 19, 2026
• Time: 12:00 PM ET/9:00AM PT
• Venue: West Shore Home Field at Beaver Stadium

College football Week 3 promos

Make the most of Dimers' Buffalo vs. Penn State predictions by exploring the Underdog Fantasy offer below:

Plus, check out the latest details on the current offer from Polymarket.

Conclusion

We predict Penn State, with a 99.4% win probability, will likely beat Buffalo in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.