Titans vs. Cardinals Predictions: Bet365 Boost on Murray, Carter, and Arizona Win

Sunday’s late-afternoon NFL action heads to Glendale, where the Arizona Cardinals host the Tennessee Titans in a Week 5 showdown at State Farm Stadium. Arizona enters as a touchdown favorite, while Tennessee looks to regroup after an inconsistent start to the season.

Bet365 Sportsbook has rolled out a “Fly With the Cardinals” Bet Boost, now paying +325 (boosted from +300) if Arizona wins and its top offensive stars deliver. The boost combines Kyler Murray’s arm and Michael Carter’s rushing ability—two key factors for a Cardinals win.

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Bet365 Featured Boost: “Fly With the Cardinals” (+325)

• Cardinals moneyline
• Kyler Murray: 200+ passing yards
• Michael Carter: 50+ rushing yards
• Boosted odds: +325 (was +300)
• Available at: Bet365 Sportsbook

This Bet Boost highlights Arizona’s balanced offense and home-field edge. With Kyler Murray expected to surpass 200 passing yards and Michael Carter leading the ground game, the boost aligns with Dimers’ model projections showing Arizona as the stronger side.

Odds accurate at the time of publication and subject to change.

Game Details: Titans vs. Cardinals

• Teams: Tennessee Titans vs. Arizona Cardinals
• Date: Sunday, October 5, 2025
• Kickoff: 4:05 p.m. ET
• Location: State Farm Stadium
• Spread: Titans +7.5 (-108) | Cardinals -7.5 (-105)
• Moneyline: Titans +330 | Cardinals -405
• Total: Over/Under 41.5 (-102/-110)

Expert Prediction: Titans vs. Cardinals

Dimers’ predictive model, powered by 10,000 game simulations, gives Arizona a 79% chance to win. Despite that, Tennessee (+7.5) shows a 56% probability of covering the spread, suggesting the Titans may keep things competitive.

The 41.5-point total is a near toss-up, with a 50% chance of going either over or under based on simulated outcomes.

Titans vs. Cardinals Best Bet

Dimers’ top play for Sunday’s matchup is Titans +7.5 (-108), as the model’s probabilities show slight value on the underdog to stay within the number.

For bettors looking for a prop-based angle, Bet365’s “Fly With the Cardinals” Bet Boost (+325) provides a creative way to back the favorite, combining three correlated outcomes tied to Arizona’s offensive efficiency.

Score Prediction for Titans vs. Cardinals

After 10,000 simulations, Dimers projects: Cardinals 24, Titans 16

The projection points to Arizona maintaining control while Tennessee covers, with scoring likely falling close to the posted total.

Final Thoughts

The Week 5 matchup between the Titans and Cardinals offers value on both sides of the board. Dimers’ model leans toward Tennessee to cover, while Bet365’s +325 “Fly With the Cardinals” boost provides added upside for bettors confident in Kyler Murray and the Arizona offense to take care of business at home.

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