Week 4 of the NFL season continues Thursday as the Arizona Cardinals host the Seattle Seahawks under the lights at State Farm Stadium. Both NFC West rivals are desperate for an early-season win, and bettors have multiple markets to consider—including a
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Bet365 Featured Boost: Kyler Murray SGP (+900)
Bet365
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on this Kyler Murray parlay against the Seahawks:
- Cardinals Moneyline
- Kyler Murray 1+ Passing Touchdowns
- Kyler Murray Anytime Touchdown
This boost highlights Murray’s dual-threat ability, giving bettors a chance to back both his passing and rushing impact in one market. The parlay has been elevated from +725 to +900, making it one of the most intriguing TNF boosts on the board.
*Odds in this article are correct at time of publication and subject to change*
Game Details: Seahawks Vs. Cardinals
- Teams:
Seattle Seahawks vs. Arizona Cardinals
- Date:
Thursday, September 25, 2025
- Kickoff:
8:15 p.m. ET
- Location:
State Farm Stadium
- Spread:
Seahawks -1.5 (-105) | Cardinals +1.5 (-105)
- Moneyline:
Seahawks -126 | Cardinals +110
- Total:
Over/Under 43.5 (-105/-110)
Expert Prediction: Seahawks Vs. Cardinals
Dimers’ predictive model, built on 10,000 game simulations, gives the Seahawks a
58% chance of winning
in Arizona. The Cardinals still hold some value as home underdogs, with the spread projected as a true toss-up and the total of 43.5 points carrying a
54% chance of going under.
Seahawks Vs. Cardinals Best Bet:
Our top pick for Thursday’s matchup is
Seahawks moneyline (-126), supported by Dimers’ simulations. While Arizona’s boost around Kyler Murray offers upside, Seattle’s more balanced roster makes them the safer bet to grab a divisional win.
Score Prediction for Seahawks Vs. Cardinals:
Dimers projects a close contest, with a predicted final score of
Seahawks 22, Cardinals 20.
NFL Player Props: Thursday
Seattle Seahawks
- First touchdown scorer predictions:
Kenneth Walker 11.3%, Jaxon Smith-Njigba 8.4%, Zach Charbonnet 8.1%
- Anytime touchdown predictions:
Kenneth Walker 45.7%, Jaxon Smith-Njigba 36.2%, Zach Charbonnet 35.3%
- Projected leaders:
Sam Darnold 229 passing yards, Smith-Njigba 87 receiving yards, Walker 55 rushing yards
Arizona Cardinals
- First touchdown scorer predictions:
Trey Benson 10.2%, Marvin Harrison Jr. 7.8%, Trey McBride 7.7%
- Anytime touchdown predictions:
Benson 37.3%, Harrison 30.0%, McBride 29.5%
- Projected leaders:
Kyler Murray 219 passing yards, McBride 64 receiving yards, Benson 60 rushing yards
Final Thoughts
Thursday night’s matchup offers a great betting menu for both conservative and aggressive players. Seattle may be favored, but Kyler Murray’s ability to swing games with both his arm and legs makes the
an enticing option. Whether you lean on the model’s projection or ride the boost, this game should deliver drama under the primetime spotlight.
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