Colorado vs. Houston Predictions Revised Following Updated Player Props For Joseph Williams

Friday Night Football in Week 3 of the college season features Colorado on the road against Houston at TDECU Stadium. Alongside data-driven predictions from Dimers, Bet365 has rolled out a special odds boost centered on Buffaloes wideout Joseph Williams.

New College Football Odds Boost from Bet365:

Bet365’s latest featured boost gives Colorado backers a chance to ride with Joseph Williams’ big-play ability:

• Prime Time Win (+1000, was +825):

• Colorado Moneyline + Joseph Williams 50+ Receiving Yards + Joseph Williams Anytime Touchdown ($10 returns $110).

This boosted parlay ties the Buffs’ upset hopes directly to Williams’ production as a top receiving threat.

Note: College football odds in this article are correct at time of publication and subject to change.

Game Details: Colorado vs. Houston

• Teams: Colorado Buffaloes vs. Houston Cougars

• Date: Friday, September 12, 2025

• Kickoff: 7:30 p.m. ET

• Venue: TDECU Stadium (Houston, TX)

• Spread: Colorado +4.0 (-110) | Houston -4.0 (-110)

• Moneyline: Colorado +165 | Houston -200

• Total: O/U 45.0 (-110)

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Dimers Prediction: Colorado vs. Houston

Dimers’ advanced model has simulated this matchup 10,000 times.

The results give Houston a 60% chance of victory, leaving Colorado with a 40% chance to win outright. Against the spread, Houston is favored by -4.5, while the total of 45.5 points leans slightly toward a lower-scoring game.

Colorado vs. Houston Best Bet

Dimers’ top betting recommendation is to lean Houston on the moneyline at -184, while those looking for value could back Colorado with the points at +4.5 (-110).

Score Prediction for Colorado vs. Houston

Across 10,000 simulations, Dimers projects a final score of Houston 25, Colorado 21. This projection reflects an expected tight contest, with Houston holding the edge at home.

Final Thoughts: Colorado vs. Houston Week 3

Friday night’s matchup is a test of Colorado’s ability to pull off a road upset against a disciplined Houston side. With Bet365’s odds boost built around Joseph Williams’ receiving impact, bettors have a chance to tie player performance directly to the Buffaloes’ chances of shocking the Cougars.

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To make sure you get accurate and helpful information, this guide has been edited by Nick Slade as part of our fact-checking process.