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Read Article Seahawks vs. Cardinals prediction: Why Seattle is favored to win in NFL Week 2 [2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Dimers' simulation model projects a 61.2% win probability for the Seahawks at State Farm Stadium.
The Arizona Cardinals will square off with the Seattle Seahawks in NFL Week 2 action at State Farm Stadium on Sunday, commencing at 4:25 PM ET.
Dimers' advanced NFL model projects the Seahawks as the most likely winner in this Seahawks vs. Cardinals prediction.
This article offers further insights into this week's matchup, including projected touchdown scorers, best bets and player prop picks.
Seahawks vs. Cardinals prediction and odds
Since our Seahawks-Cardinals predictions earlier in the week, we have re-simulated the outcome of Sunday's NFL game between the Seahawks and Cardinals, forming part of our NFL predictions coverage.
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Our famous predictive model currently gives the Seahawks a 61.2% chance of beating the Cardinals in Week 2 of the NFL season. Our predicted final score has the Seahawks winning 22-19.
Key factors favoring the Seahawks:
- Seattle Seahawks Power Rankings
- Arizona Cardinals QB Change / Form
- Seattle Seahawks Defensive Efficiency
According to our model, the Cardinals (+3.5) have a 55.2% chance of covering the spread, while the 41.5-point over/under has a 50.6% chance of going over.
The main contributing factors to the over being more likely are:
- Weather / Conditions
- Seattle Seahawks Form
To see win probabilities for every matchup this week, check out our expert NFL Week 2 straight up picks.
Latest betting odds
We have researched the best NFL odds in America for this game, which are listed here:
- Spread: Seahawks -3.5 (-104) / Cardinals +3.5 (+102)
- Moneyline: Seahawks -190, Cardinals +186
- Total: Over/Under 41.5 (+104/-106)
All odds are correct at the time of publication and are subject to change.
Model picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Spread: Cardinals +3.5 @ 50¢ via Novig
- Moneyline: Cardinals @ 35¢ via Novig
- Total: Over 41.5 @ 49¢ via Polymarket
According to our NFL best bets, the top play to make on this game is Cardinals +3.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the current available odds.
Seahawks vs. Cardinals TD scorers
Who will score a touchdown in Seahawks vs. Cardinals?
According to our list of touchdown scorer predictions for Week 2, Jaxon Smith-Njigba is most likely to score an anytime TD in Seahawks vs. Cardinals.
Our projections give Smith-Njigba a 37.3% chance of scoring a TD at State Farm Stadium, while the running back is a 9.5% chance of registering the first touchdown the game.
Anytime touchdown scorer predictions
Seattle Seahawks
- Jaxon Smith-Njigba (WR): 37.3% probability
- Jadarian Price (RB): 35.8%
- George Holani (RB): 29.1%
- AJ Barner (TE): 21.9%
- Rashid Shaheed (WR): 18.0%
Arizona Cardinals
- Jeremiyah Love (RB): 32.9% prob.
- Trey McBride (TE): 27.7%
- Tyler Allgeier (RB): 25.6%
- Marvin Harrison (WR): 20.3%
- Michael Wilson (WR): 19.6%
First touchdown scorer predictions
Seattle Seahawks
- Jaxon Smith-Njigba (WR): 9.5% prob.
- Jadarian Price (RB): 9.0%
- George Holani (RB): 7.0%
- AJ Barner (TE): 5.0%
- Rashid Shaheed (WR): 4.0%
Arizona Cardinals
- Jeremiyah Love (RB): 9.8% prob.
- Trey McBride (TE): 8.0%
- Tyler Allgeier (RB): 7.2%
- Marvin Harrison (WR): 5.6%
- Michael Wilson (WR): 5.3%
Top player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Seahawks and Cardinals. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 2 games.
Quarterbacks
Of the starting quarterbacks, the Seahawks' Drew Lock is projected for 205 passing yards. The Cardinals' Jacoby Brissett is expected to throw for 223 yards.
Seahawks rushing
- Jadarian Price: 66 yds
- George Holani: 31 yds
- Drew Lock: 13 yds
Cardinals rushing
- Jeremiyah Love: 42 yds
- Tyler Allgeier: 36 yds
- Jacoby Brissett: 13 yds
Seahawks receiving
- Jaxon Smith-Njigba: 84 yds
- Rashid Shaheed: 30 yds
- Cooper Kupp: 29 yds
- AJ Barner: 27 yds
- Elijah Arroyo: 15 yds
Cardinals receiving
- Trey McBride: 62 yds
- Michael Wilson: 44 yds
- Marvin Harrison: 42 yds
- Kendrick Bourne: 31 yds
- Jeremiyah Love: 20 yds
Game info & kickoff details
The NFL Week 2 game between the Cardinals and Seahawks at State Farm Stadium is scheduled to start at 4:25 PM ET.
- Who: Seattle Seahawks vs. Arizona Cardinals
- Date: Sunday, September 20, 2026
- Time: 4:25 PM ET/1:25PM PT
- Venue: State Farm Stadium
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Conclusion
We predict the Seahawks, with a 61.2% win probability, will likely beat the Cardinals in Week 2 of the NFL season.
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This article's predictions and probabilities are generated by Dimers' proprietary NFL prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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