NFL picks straight up: Week 2, 2026

At Dimers, our Week 2 NFL picks are grounded in data-driven insight, with straight-up picks for all 16 games informed by our latest NFL predictions.

Get an edge in your NFL pick 'em competitions with our data-driven NFL Week 2 picks straight up, powered by thousands of game simulations.

Week 2 of the NFL season starts with the Detroit Lions facing the Buffalo Bills on Thursday night and concludied with the New York Giants taking on the Los Angeles Rams on Monday night.

NFL picks this week straight up: Week 2, 2026

Listed below are our Week 2 NFL picks highlighting how likely each team is to win their game this week.

Detroit Lions vs. Buffalo Bills

The Lions kick off Week 2 against the Bills at Highmark Stadium on Thursday night. According to our model, the Bills have a 66% chance of winning, while the Lions have a 34% chance.

For Week 2's opening game, our model highlights NFL player projections, with Jahmyr Gibbs (RB) the most likely player from the Lions to score the first TD at 19.5%, while James Cook (RB) is the top candidate from the Bills at 12.4%.

Check out our full Detroit Lions vs. Buffalo Bills prediction ahead of this week's matchup at Highmark Stadium, set for Thursday, September 17 at 8:15pm. All times mentioned in this article are in Eastern Standard Time (EST).

Philadelphia Eagles vs. Tennessee Titans

For this week's game between the Eagles and the Titans, Philadelphia is more likely to win. Our prediction model gives the Eagles a 74% chance of winning. On the other hand, there is a 26% chance that the Titans will win.

Explore the latest data in this week's Philadelphia Eagles vs. Tennessee Titans prediction before kickoff in Tennesseeon Sunday at 1:00pm.

As the season heats up, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Pittsburgh Steelers vs. New England Patriots

We are picking the Patriots to win their game against the Steelers this week, with our powerful NFL model projecting a 71% win probability for the home team. The Steelers have a 29% chance of winning at Gillette Stadium.

For betting purposes, the Patriots are listed as -5.5 favorites, with the Steelers' moneyline at +205.

Find the complete Pittsburgh Steelers vs. New England Patriots prediction for a closer look at Sunday's 1:00pm game.

Minnesota Vikings vs. Chicago Bears

According to our predictive analytics model, the Bears are the team to beat in this game, with their win probability at 67%. The Vikings, on the other hand, have a 33% chance of winning.

Review the edges and numbers in our Minnesota Vikings vs. Chicago Bears prediction for this Sunday 1:00pm clash at Soldier Field.

Carolina Panthers vs. Atlanta Falcons

The Panthers have a 55% chance of winning on Sunday afternoon, compared to the Falcons' 45% chance of victory. This makes the Carolina Panthers our pick to win at Mercedes-Benz Stadium.

See the numbers behind this matchup in the full Carolina Panthers vs. Atlanta Falcons prediction scheduled for Sunday at 1:00pm at Mercedes-Benz Stadium.

Green Bay Packers vs. New York Jets

The Packers are favored to win their Week 2 matchup, with our model giving them a 65% chance, while the Jets enter the weekend with a 35% chance of causing an upset at MetLife Stadium.

When it comes to betting on this game, the Packers' moneyline odds are set at -200, with the home team Jets listed as +3.5 underdogs.

This week's Green Bay Packers vs. New York Jets prediction highlights the top values for the game at MetLife Stadium on Sunday, September 20 at 1:00pm.

New Orleans Saints vs. Baltimore Ravens

After 10,000 simulations of Saints vs. Ravens this Sunday, our model projects the Ravens as the more likely winners with a probability of 76%. Their opponents, the Saints, have a 24% chance of getting the win on the road.

Compare projections and odds for this matchup in our New Orleans Saints vs. Baltimore Ravens prediction, set for Sunday at 1:00pm.

Cincinnati Bengals vs. Houston Texans

We are picking the Texans, who have a 56% chance of winning the matchup, while the Bengals have a 44% win probability.

Access the full data breakdown in our Cincinnati Bengals vs. Houston Texans prediction ahead of kickoff at Reliant Stadium.

Cleveland Browns vs. Tampa Bay Buccaneers

The next game of Week 2 sees the Browns take on the Buccaneers at Raymond James Stadium.

We predict the Buccaneers to win with a probability of 76%, while the Browns are projected to have a win chance of 24%.

As for the Vegas betting odds here, the Buccaneers are listed as -8.5 favorites, with the Browns' moneyline odds posted at +360.

Breakdown further probabilities and player projections in the Cleveland Browns vs. Tampa Bay Buccaneers prediction for Sunday, September 20 at 1:00pm.

Jacksonville Jaguars vs. Denver Broncos

The likely winner of this matchup is the Broncos, who have a projected win chance of 57%, according to DimersBOT. On the other side of this matchup, the Jaguars have a projected win probability of 43%.

Check out our Jacksonville Jaguars vs. Denver Broncos prediction to see where the rest of the numbers lean ahead of Sunday's game in Denver.

Las Vegas Raiders vs. Los Angeles Chargers

We have run our powerful NFL model over this week’s Raiders-Chargers clash 10,000 times, with the Chargers coming out as the team to pick. Of those 10,000 simulations, the Chargers won 7,229 times, with the Raiders winning on 2,771 occasions.

Get direct access to more game projections with our Las Vegas Raiders vs. Los Angeles Chargers prediction before Sunday's clash at SoFi Stadium

Seattle Seahawks vs. Arizona Cardinals

Next up is the game between the Seahawks and Cardinals, with our model projecting the road team as the more likely victor, with the Seahawks rated as having a 63% chance of getting the W. The Cardinals, on the other hand, are projected to have a 37% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Seahawks' moneyline odds set at -220 for this road game, while the hosting Cardinals are listed as +4.5 underdogs.

Examine further probabilities in the full Seattle Seahawks vs. Arizona Cardinals prediction, scheduled for Sunday at 4:25pm.

Miami Dolphins vs. San Francisco 49ers

Our next straight up pick this week is for the 49ers to get the win against the Dolphins. After running 10,000 simulations of this matchup, the San Francisco have a win probability of 86%, with the Dolphins at 14%.

View the complete Miami Dolphins vs. San Francisco 49ers prediction for a deeper look at this Sunday's game in San Francisco.

Washington Commanders vs. Dallas Cowboys

With a win probability of 61% on Sunday afternoon, our straight up pick for this matchup is the Cowboys, while their opponent, the Commanders, have a projected win chance of 39%.

Check out the latest projections in this week's Washington Commanders vs. Dallas Cowboys prediction before kickoff on Sunday, September 20 at 4:25pm.

Indianapolis Colts vs. Kansas City Chiefs

The team to pick here is the Chiefs, who have a 70% chance of winning their matchup against the Colts this Sunday night.

Looking at the betting odds for this Sunday Night Football clash, the Chiefs are listed as -6.5 favorites at home, with the Colts' moneyline odds available at +270.

Find all game probabilities and odds in the full Indianapolis Colts vs. Kansas City Chiefs prediction for Sunday's matchup at Arrowhead Stadium.

New York Giants vs. Los Angeles Rams

Our pick to win the final game of Week 2 is the Rams, who have a win probability of 76%. Their opponents are projected to have a 24% chance of getting the W.

See where the projections identify value in our New York Giants vs. Los Angeles Rams prediction, set for Monday at 8:15pm at SoFi Stadium.

Full list of NFL Week 2 picks straight up

This week's most likely NFL winners, ordered by probability:

• 49ers 86.1% vs. Dolphins
• Ravens 76.3% vs. Saints
• Rams 75.8% vs. Giants
• Buccaneers 75.7% vs. Browns
• Eagles 74.2% @ Titans
• Chargers 72.3% vs. Raiders
• Patriots 70.7% vs. Steelers
• Chiefs 70.1% vs. Colts
• Bears 67.1% vs. Vikings
• Bills 65.9% vs. Lions
• Packers 64.7% @ Jets
• Seahawks 62.6% @ Cardinals
• Cowboys 61.1% vs. Commanders
• Broncos 57.4% vs. Jaguars
• Texans 56.4% vs. Bengals
• Panthers 55.4% @ Falcons

NFL straight up picks and predictions for Week 2

The NFL Week 2 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.