Seahawks vs. Cardinals: NFL Week 2 Prediction, Picks & Odds
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Seahawks vs. Cardinals: Detailed Breakdown
Matchup overview: NFL Week 2
- Teams: Seattle Seahawks vs. Arizona Cardinals
- Date: Sunday, September 20, 2026
- Time: 4:25PM ET
- Venue: State Farm Stadium
Current betting odds
- Spread: Seahawks (-10, -106), Cardinals (+10, -110)
- Moneyline: Seahawks -530, Cardinals +410
- Total (Over/Under): 44.5 points (-109/-110)
Dimers’ win probabilities
- Seahawks: 79.1%
- Cardinals: 20.9%
These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.
Projected final score
Our predicted final score for this NFL matchup is Seahawks 27-17 Cardinals.
This prediction draws on each team's scoring trends and player stats, weighed across both of our data models.
Our Prediction: Who Wins?
The numbers give the Seahawks a win probability of 79.1%, while the Cardinals have a win probability of 20.9%.
Summary
The Seahawks face off against the Cardinals in the NFL at State Farm Stadium on Sunday, September 20, 2026.
Our Seahawks vs. Cardinals predictions, built on real-time data and matchup-specific modeling, help guide your decisions.. Remember to bet responsibly and within your financial limits.
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For further insights, explore our expert NFL predictions and the best NFL bets today, while our in-depth analysis includes NFL props, NFL futures, NFL odds, and the latest NFL news.

