Dolphins vs. 49ers: NFL Week 2 Prediction, Picks & Odds

Dimers' Dolphins vs. 49ers prediction for Sunday, September 20, 2026. Win probabilities, projected final score, current odds, and picks from our NFL machine learning models.
FINAL
NFL
FINAL
NFL sport icon
NFL
Dolphins
13
35
Levi's Stadium
49ers
Levi's Stadium
Live Probabilities
Win %
  • Dolphins
    0%
  • 49ers
    100%
Win Probability
TEAM1234T
Dolphins
0 6 0 7 13
49ers
7 7 21 0 35
1 0 2 0 3 0 4 0 5 0 4 0 3 0 2 0 1 0 1 0 2 0 3 0 4 0 5 0 4 0 3 0 2 0 1 0
49ers
Dolphins
3rd and 12 at the SF 38
Last Play
End Game

Dolphins vs. 49ers: Detailed Breakdown

Matchup overview: NFL Week 2

  • Teams: Miami Dolphins vs. San Francisco 49ers
  • Date: Sunday, September 20, 2026
  • Time: 4:25PM ET
  • Venue: Levi's Stadium

Current betting odds

  • Spread: Dolphins (+12.5, -104), 49ers (-12.5, +100)
  • Moneyline: Dolphins +809, 49ers -869
  • Total (Over/Under): 44.5 points (-108/+104)

Dimers’ win probabilities

  • Dolphins: 13.5%
  • 49ers: 86.5%

These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.

Projected final score

Our predicted final score for this NFL matchup is Dolphins 15-28 49ers.

This prediction draws on each team's scoring trends and player stats, weighed across both of our data models

Our Prediction: Who Wins?

The numbers give the Dolphins a win probability of 13.5%, while the 49ers have a win probability of 86.5%.

Summary

The Dolphins face off against the 49ers in the NFL at Levi's Stadium on Sunday, September 20, 2026.

Our Dolphins vs. 49ers predictions, built on real-time data and matchup-specific modeling, help guide your decisions.. Remember to bet responsibly and within your financial limits.

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For further insights, explore our expert NFL predictions and the best NFL bets today, while our in-depth analysis includes NFL props, NFL futures, NFL odds, and the latest NFL news.