Dolphins vs. 49ers: NFL Week 2 Prediction, Picks & Odds
Spread
- Dolphins
- 49ers
- De'Von Achane50.8%
- Malik Willis32.0%
- Malik Washington23.4%
- Caleb Douglas
- Chris Bell
- Christian McCaffrey57.1%
- Mike Evans44.3%
- George Kittle34.8%
- Deebo Samuel
- Kaelon Black
| Player | Proj. Yards |
|---|---|
| M. Willis |
| Player | Proj. Yards |
|---|---|
| B. Purdy |
| Player | Touchdown %TD% | Proj. Yards |
|---|---|---|
| D. Achane | ||
| M. Willis | ||
| J. Wright |
| Player | Touchdown %TD% | Proj. Yards |
|---|---|---|
| C. McCaffrey | ||
| K. Black | ||
| B. Purdy |
| Player | Touchdown %TD% | Proj. Yards |
|---|---|---|
| C. Douglas | ||
| M. Washington | ||
| C. Bell | ||
| D. Achane | ||
| G. Dulcich |
| Player | Touchdown %TD% | Proj. Yards |
|---|---|---|
| M. Evans | ||
| D. Samuel | ||
| G. Kittle | ||
| C. McCaffrey | ||
| D. Robinson |
Dolphins vs. 49ers: Detailed Breakdown
Matchup overview: NFL Week 2
- Teams: Miami Dolphins vs. San Francisco 49ers
- Date: Sunday, September 20, 2026
- Time: 4:25PM ET
- Venue: Levi's Stadium
Current betting odds
- Spread: Dolphins (+13.5, -108), 49ers (-13.5, +104)
- Moneyline: Dolphins +756, 49ers -809
- Total (Over/Under): 45.5 points (-104/+104)
Dimers’ win probabilities
- Dolphins: 13.9%
- 49ers: 86.1%
These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.
Projected final score
Our predicted final score for this NFL matchup is Dolphins 15-28 49ers.
This prediction draws on each team's scoring trends and player stats, weighed across both of our data models.
Our Prediction: Who Wins?
The numbers give the Dolphins a win probability of 13.9%, while the 49ers have a win probability of 86.1%.
Summary
The Dolphins face off against the 49ers in the NFL at Levi's Stadium on Sunday, September 20, 2026.
Our Dolphins vs. 49ers predictions, built on real-time data and matchup-specific modeling, help guide your decisions.. Remember to bet responsibly and within your financial limits.
For additional resources and advice on responsible gambling please call 1-800-GAMBLER.
When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.
For further insights, explore our expert NFL predictions and the best NFL bets today, while our in-depth analysis includes NFL props, NFL futures, NFL odds, and the latest NFL news.