Giants vs. Cubs Prediction: Cubs Predicted to Win Wednesday's MLB Matchup [5/7/2025]

The Chicago Cubs and San Francisco Giants are scheduled to meet in MLB action at Wrigley Field on Wednesday, starting at 2:20PM ET.

Ben Brown (3-2, 4.88 ERA) will be on the bump for the Cubs, pitting him against Robbie Ray (4-0, 3.05 ERA) for the Giants.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's San Francisco-CHI Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cubs' chance of winning at 57%, with the Giants at 43%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Giants vs. Cubs predictions page.

Cubs vs. Giants Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Giants and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cubs a 57% chance of beating the Giants.

According to our model, the Giants (+1.5) have a 63% chance of covering the run line, while the 7.5-run over/under has a 55% chance of staying under.

Giants vs. Cubs Odds [5/7/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Giants	Cubs
Run Line	+1.5 (-162)	-1.5 (+145)
Moneyline	+138	-145
Total	o7.5 (-102)	u7.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Giants vs. Cubs Picks and Best Bets

Our model's strongest edge in today's Giants vs. Cubs matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Giants vs. Cubs Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Cubs and Giants at Wrigley Field is scheduled to commence at 2:20PM ET.

• Who: San Francisco Giants vs. Chicago Cubs
• Date: Wednesday, May 7, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Wednesday's Giants vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any San Francisco vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cubs, with a 57% win probability, will likely beat the Giants on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Giants vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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