Red Sox vs. Reds Prediction and Odds - Sep 21, 2022

MLB action continues on Wednesday at 6:40PM ET as the Boston Red Sox lock horns with the Cincinnati Reds at Great American Ball Park.

Chase Anderson (1-3, 6.43 ERA) will start for the Reds, pitting him against Connor Seabold (0-2, 11.91 ERA) for the Red Sox.

Dimers' top betting picks for Red Sox vs. Reds, as well as game predictions and best odds, are detailed below.

Who will win Red Sox vs. Reds?

Based on advanced machine learning and data, Dimers.com has simulated Wednesday's Red Sox-Reds MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the Red Sox a 59% chance of getting the W against the Reds.

More: Red Sox vs. Reds Simulated 10,000 Times

Red Sox vs. Reds Current Odds

• Run Line: Reds +1.5 (-115), Red Sox -1.5 (+100)
• Moneyline: Reds +135, Red Sox -148
• Total: Over/Under 10 (-120/+100)

Run Line, Moneyline and Over/Under

The Reds are +1.5 underdogs versus the Red Sox, with -115 at BetMGM the best odds currently available.

For the favored Red Sox (-1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at +100.

DraftKings Sportsbook currently has the best moneyline odds for the Reds at +135. That means you can bet $100 to profit $135, earning a total payout of $235, if they win.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Red Sox at -148, where you can risk $148 to win $100, for a total payout of $248, if they come out on top.

The Over/Under sits at 10 with Caesars Sportsbook, which currently has the best odds for the Over at -120, as well as the best odds for the Under at +100.

As always, check out all of the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Reds (+1.5) are a 53% chance of covering the run line, while the Over/Under total of 10 runs is a 56% chance of going Over.

More: Best Free Bet Tracker

Best Bets for Red Sox vs. Reds

• Run Line: Reds +1.5 @ -115 via BetMGM (53% probability)
• Moneyline: Red Sox @ -148 via FanDuel Sportsbook (59% probability)
• Total: Over 10 @ -120 via Caesars Sportsbook (56% probability)

Dimers' best bets are based on world-class simulations and wagering intelligence to help you make more informed investments with your state's legal sportsbooks.

Red Sox vs. Reds Prediction

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Dimers has full betting coverage of Wednesday's Red Sox-Reds matchup, including pregame predictions, computer picks, and live scores.

Remember, DimersBOT updates often, so refresh this page for the latest betting insights before Red Sox vs. Reds on Wednesday September 21, 2022.

Red Sox vs. Reds 2022 Game Info

Wednesday's game between the Reds and Red Sox at Great American Ball Park is scheduled to start at 6:40PM ET.

• Who: Boston Red Sox vs. Cincinnati Reds
• Date: Wednesday September 21, 2022
• Time: 6:40PM ET / 3:40PM PT
• Venue: Great American Ball Park

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