Rays vs. Guardians Prediction and Odds - Sep 28, 2022

MLB action continues on Wednesday at 6:10PM ET as the Tampa Bay Rays take on the Cleveland Guardians at Progressive Field.

The Guardians will send Triston McKenzie (11-11, 3.04 ERA) to the mound, while the Rays will counter with Tyler Glasnow (0-0, 0.00 ERA).

Dimers' top betting picks for Rays vs. Guardians, plus game predictions and best odds, are featured in this article.

Who will win Rays vs. Guardians?

Using state-of-the-art machine learning and data, Dimers.com has simulated Wednesday's Rays-Guardians MLB game 10,000 times.

Dimers' proven predictive analytics model, DimersBOT, gives the Guardians a 54% chance of defeating the Rays.

More: Free Betting Analysis for Rays vs. Guardians

Rays vs. Guardians Current Odds

• Run Line: Guardians -1.5 (+180), Rays +1.5 (-205)
• Moneyline: Guardians -125, Rays +112
• Total: Over/Under 6 (-115/+100)

Run Line, Moneyline and Over/Under

The Guardians are -1.5 favorites against the Rays, with +180 at BetMGM the best odds currently available.

For the underdog Rays (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on the market at -205.

BetMGM currently has the best moneyline odds for the Guardians at -125. That means you can risk $125 to win $100, for a total payout of $225, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Rays at +112, where you can put down $100 to profit $112, earning a total payout of $212, if they win.

The Over/Under for total runs scored sits at 6 with Caesars Sportsbook, which currently has the best odds for the Over at -115, while BetMGM currently has the best odds for the Under at +100.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Rays (+1.5) are a 67% chance of covering the run line, while the 6-run Over/Under is a 61% chance of going Over.

More: Track Your Bets via Bet Center

Best Bets for Rays vs. Guardians

• Run Line: Rays +1.5 @ -205 via DraftKings Sportsbook (67% probability)
• Moneyline: Rays @ +112 via FanDuel Sportsbook
• Total: Over 6 @ -115 via Caesars Sportsbook (61% probability) 🔥

Any time you see a 🔥, that means you've found one of our best bets today across any sport.

Our best bets are based on detailed simulations and gambling intelligence to bring you the best possible plays 24/7/365.

While the Guardians are more likely to win the game, according to DimersBOT, taking the Rays moneyline is the best option because of the edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published on Dimers.com is pivotal to being profitable in the long run.

Rays vs. Guardians Prediction

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Dimers has full coverage of Wednesday's Rays-Guardians matchup, including pregame predictions, free betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep an eye on this article for any changes to our betting insights before Rays vs. Guardians on Wednesday September 28, 2022.

Rays vs. Guardians 2022 Game Info

Wednesday's action between the Guardians and Rays at Progressive Field is scheduled to begin at 6:10PM ET.

• Who: Tampa Bay Rays vs. Cleveland Guardians
• Date: Wednesday September 28, 2022
• Time: 6:10PM ET / 3:10PM PT
• Venue: Progressive Field

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