Pirates vs. Reds Prediction and Odds - Sep 14, 2022

MLB action continues on Wednesday at 12:35PM ET as the Pittsburgh Pirates lock horns with the Cincinnati Reds at Great American Ball Park.

The Reds will have Nick Lodolo (4-5, 3.78 ERA) start, pitting him against Roansy Contreras (5-4, 3.29 ERA) for the Pirates.

Dimers' top betting picks for Pirates vs. Reds, as well as game predictions and best odds, are featured in this article.

Who will win Pirates vs. Reds?

Using state-of-the-art machine learning and data, Dimers.com has simulated Wednesday's Pirates-Reds MLB matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, gives the Reds a 58% chance of winning against the Pirates.

More: Pirates vs. Reds Simulated 10K Times

Pirates vs. Reds Game Odds

• Run Line: Reds -1.5 (+140), Pirates +1.5 (-160)
• Moneyline: Reds -155, Pirates +135
• Total: Over/Under 7.5 (-115/-105)

Run Line, Moneyline and Over/Under

The Reds are currently -1.5 favorites against the Pirates, with +140 at DraftKings Sportsbook the best odds currently available.

For the underdog Pirates (+1.5) to cover the run line, BetMGM has the best odds currently on offer at -160.

BetMGM currently has the best moneyline odds for the Reds at -155. That means you can risk $155 to win $100, for a total payout of $255, if they get the W.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Pirates at +135, where you can bet $100 to profit $135, earning a total payout of $235, if they win.

The Over/Under sits at 7.5 with Caesars Sportsbook, which currently has the best odds for the Over at -115, while BetMGM currently has the best odds for the Under at -105.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Pirates (+1.5) are a 61% chance of covering the run line, while the 7.5-run Over/Under is a 52% chance of going Over.

More: Free Prop Picks

Best Bets for Pirates vs. Reds

• Run Line: Pirates +1.5 @ -160 via BetMGM (61% probability)
• Moneyline: Pirates @ +135 via DraftKings Sportsbook
• Total: Over 7.5 @ -115 via Caesars Sportsbook (52% probability)

Our best bets are based on world-class modeling and wagering expertise to help you make smarter decisions with the legal sportsbooks in America.

While the Reds are more likely to win the game, according to DimersBOT, taking the Pirates moneyline is the best option because of the edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges published here at Dimers.com is one of the keys to achieving long-term profitability.

Pirates vs. Reds Prediction

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Dimers has full coverage of Wednesday's Pirates-Reds matchup, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so keep checking this page for the latest betting insights before Pirates vs. Reds on Wednesday September 14, 2022.

Pirates vs. Reds 2022 Game Info

Wednesday's game between the Reds and Pirates at Great American Ball Park is scheduled to begin at 12:35PM ET.

• Who: Pittsburgh Pirates vs. Cincinnati Reds
• Date: Wednesday September 14, 2022
• Time: 12:35PM ET / 9:35AM PT
• Venue: Great American Ball Park

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What other MLB games are on today?

Now you've got the 411 on Pirates vs. Reds, check out the latest betting analysis for all upcoming MLB games in our MLB Bet Hub. There you can find probabilities and odds, and our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds available.