Padres vs. Mariners Prediction and Odds - Sep 14, 2022

The Seattle Mariners and San Diego Padres meet in MLB at T-Mobile Park on Wednesday, starting at 4:10PM ET.

The Mariners will have Luis Castillo (6-5, 2.80 ERA) start, while the Padres will counter with Mike Clevinger (5-6, 4.13 ERA).

Dimers' best betting picks for Padres vs. Mariners, as well as game predictions and betting odds, are featured below.

Who will win Padres vs. Mariners?

Based on cutting-edge machine learning and data, Dimers.com has simulated Wednesday's Padres-Mariners MLB game 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the Mariners a 59% chance of defeating the Padres.

More: Full Betting Analysis for Padres vs. Mariners

Padres vs. Mariners Current Odds

• Run Line: Mariners -1.5 (+140), Padres +1.5 (-150)
• Moneyline: Mariners -161, Padres +145
• Total: Over/Under 7.5 (+100/-120)

Run Line, Moneyline and Over/Under

The Mariners are listed as -1.5 favorites versus the Padres, with +140 at Caesars Sportsbook the best odds currently available.

For the underdog Padres (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on the market at -150.

Caesars Sportsbook currently has the best moneyline odds for the Mariners at -161. That means you can risk $161 to win $100, for a total payout of $261, if they get the W.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Padres at +145, where you can put down $100 to profit $145, earning a total payout of $245, if they win.

The Over/Under for total runs scored sits at 7.5 with BetMGM, which currently has the best odds for the Over at +100, as well as the best odds for the Under at -120.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Padres (+1.5) are a 60% chance of covering the run line, while the 7.5-run Over/Under is considered an equal 50-50 chance of hitting.

More: Best Prop Bets Today

Best Bets for Padres vs. Mariners

• Run Line: Padres +1.5 @ -150 via DraftKings Sportsbook (60% probability)
• Moneyline: Padres @ +145 via DraftKings Sportsbook (0.4% edge)
• Total: Over 7.5 @ +100 via BetMGM (50% probability)

Dimers' best bets are based on detailed simulations and betting expertise to help you make more informed decisions with your state's legal sportsbooks.

While the Mariners are more likely to win the game, according to DimersBOT, betting on the Padres moneyline is the best option because of the edge found when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges published on Dimers is one of the keys to achieving long-term profitability.

Padres vs. Mariners Betting Guide

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Dimers has full betting coverage of Wednesday's Padres-Mariners matchup, including pregame predictions, top betting picks, and live win probabilities.

Remember, DimersBOT updates frequently, so refresh this article for any changes to our betting analysis ahead of Padres vs. Mariners on Wednesday September 14, 2022.

Padres vs. Mariners 2022 Game Info

Wednesday's matchup between the Mariners and Padres at T-Mobile Park is scheduled to start at 4:10PM ET.

• Who: San Diego Padres vs. Seattle Mariners
• Date: Wednesday September 14, 2022
• Time: 4:10PM ET / 1:10PM PT
• Venue: T-Mobile Park

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What other MLB games are on today?

Now you've got the 411 on Padres vs. Mariners, get the latest betting coverage for all upcoming MLB games in Dimers' MLB Bet Hub. There you can find probabilities and odds, and our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.