Pacers vs. Spurs prediction: San Antonio to win, Victor Wembanyama projected for 28 points in Saturday's NBA game [3/21/2026]

The San Antonio Spurs will square off with the Indiana Pacers in NBA action at Frost Bank Center on Saturday, beginning at 8:00 PM ET.

Based on updated simulation results and today’s injury reports, Dimers' advanced NBA model projects the Spurs as the most likely winner of the Pacers vs. Spurs game.

This prediction follows the latest NBA Injury Report, which suggests the Spurs lineup will feature players like Victor Wembanyama, De'Aaron Fox and Devin Vassell, while the Pacers will be led by Pascal Siakam, Andrew Nembhard and Jarace Walker.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Pacers vs. Spurs prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Saturday's NBA game between the Pacers and Spurs 10,000 times as part of our NBA predictions coverage.

Our famous predictive model currently gives the Spurs an 88% chance of defeating the Pacers. Our predicted final score has the Spurs winning 124-110.

According to our model, the Pacers (+16) have a 59% chance of covering the spread, while the over/under total of 234.5 points has a 51% chance of staying under.

Pacers vs. Spurs odds

We have sourced the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Pacers vs. Spurs picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Saturday, the top play to make on this game is Pacers +16 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Pacers vs. Spurs player props

NBA prop bets are an enjoyable way to wager on Saturday's Pacers vs. Spurs game without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at Frost Bank Center.

Pascal Siakam is expected to lead the Pacers with 19 points, 5 rebounds and 3 assists, while Victor Wembanyama is projected to have 28 points, 12 rebounds and 4 assists for the Spurs.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.

Pacers prediction

Our model's projected player stats for the Pacers are:

Spurs prediction

Projected points, rebounds, assists and three-pointers made for the Spurs:

Pacers vs. Spurs game-day updates and essential details

Saturday's action between the Spurs and Pacers at Frost Bank Center is scheduled to start at 8:00 PM ET.

• Who: Indiana Pacers vs. San Antonio Spurs
• Date: Saturday, March 21, 2026
• Time: 8:00 PM ET/5:00PM PT
• Venue: Frost Bank Center

Conclusion

We predict the Spurs, with an 88% win probability, will likely beat the Pacers on Saturday, with Victor Wembanyama projected for a game-high 59 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Pacers vs. Spurs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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