Cardinals vs. Padres Prediction and Odds - Sep 20, 2022

The San Diego Padres square off with the St. Louis Cardinals in MLB action at PETCO Park on Tuesday, beginning at 9:40PM ET.

The Padres will send Mike Clevinger (5-7, 4.47 ERA) to the mound, pitting him against Adam Wainwright (11-9, 3.29 ERA) for the Cardinals.

Dimers' top betting picks for Cardinals vs. Padres, as well as game predictions and best odds, are detailed below.

Who will win Cardinals vs. Padres?

Based on cutting-edge machine learning and data, Dimers.com has simulated Tuesday's Cardinals-Padres MLB game 10,000 times.

Dimers' proven predictive analytics model, DimersBOT, currently gives the Padres a 52% chance of beating the Cardinals.

More: Full Betting Analysis for Cardinals vs. Padres

Cardinals vs. Padres Current Odds

• Run Line: Padres +1.5 (-190), Cardinals -1.5 (+165)
• Moneyline: Padres -110, Cardinals +102
• Total: Over/Under 8 (+100/-110)

Run Line, Moneyline and Over/Under

The Padres are listed as +1.5 underdogs against the Cardinals, with -190 at BetMGM the best odds currently available.

For the favored Cardinals (-1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at +165.

BetMGM currently has the best moneyline odds for the Padres at -110. That means you can risk $110 to win $100, for a total payout of $210, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Cardinals at +102, where you can put down $100 to profit $102, earning a total payout of $202, if they win.

The Over/Under for total runs scored is set at 8 with DraftKings Sportsbook, which currently has the best odds for the Over at +100, while Caesars Sportsbook currently has the best odds for the Under at -110.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Padres (+1.5) are a 64% chance of covering the run line, while the 8-run Over/Under is a 54% chance of going Over.

More: Best Bets for Every MLB Game

Best Bets for Cardinals vs. Padres

• Run Line: Padres +1.5 @ -190 via BetMGM (64% probability)
• Moneyline: Padres @ -110 via BetMGM (52% probability)
• Total: Over 8 @ +100 via DraftKings Sportsbook (54% probability)

Dimers' best bets are based on world-class modeling and wagering intelligence to bring you the best possible plays 24/7.

Cardinals vs. Padres Prediction

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Dimers has full coverage of Tuesday's Cardinals-Padres matchup, including pregame predictions, top betting picks, and live scores.

Remember, DimersBOT updates frequently, so keep an eye on this article for any changes to our betting analysis before Cardinals vs. Padres on Tuesday September 20, 2022.

Cardinals vs. Padres 2022 Game Info

Tuesday's matchup between the Padres and Cardinals at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: St. Louis Cardinals vs. San Diego Padres
• Date: Tuesday September 20, 2022
• Time: 9:40PM ET / 6:40PM PT
• Venue: PETCO Park

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What MLB games are on today?

Now you've got the 411 on Cardinals vs. Padres, check out the latest betting coverage for all upcoming MLB games in our MLB Bet Hub, where you can find probabilities and odds, as well as our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.