Astros vs. Rays Prediction and Odds - Sep 21, 2022

The Tampa Bay Rays take on the Houston Astros in MLB action at Tropicana Field on Wednesday, beginning at 6:40PM ET.

Corey Kluber (10-9, 4.44 ERA) will be on the bump for the Rays, while the Astros are going with Lance McCullers Jr. (3-1, 2.34 ERA).

Dimers' top betting picks for Astros vs. Rays, plus game predictions and best odds, are featured in this article.

Who will win Astros vs. Rays?

Based on state-of-the-art machine learning and data, Dimers.com has simulated Wednesday's Astros-Rays MLB game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Astros a 55% chance of defeating the Rays.

More: Astros vs. Rays Simulated 10,000 Times

Astros vs. Rays Current Odds

• Run Line: Rays +1.5 (-162), Astros -1.5 (+140)
• Moneyline: Rays +112, Astros -125
• Total: Over/Under 7 (+100/-110)

Run Line, Moneyline and Over/Under

The Rays are listed as +1.5 underdogs versus the Astros, with -162 at FanDuel Sportsbook the best odds currently available.

For the favored Astros (-1.5) to cover the run line, BetMGM has the best odds currently on offer at +140.

FanDuel Sportsbook currently has the best moneyline odds for the Rays at +112. That means you can bet $100 to profit $112, earning a total payout of $212, if they win.

On the other hand, BetMGM currently has the best moneyline odds for the Astros at -125, where you can risk $125 to win $100, for a total payout of $225, if they come out on top.

The Over/Under for total runs scored sits at 7 with DraftKings Sportsbook, which currently has the best odds for the Over at +100, while BetMGM currently has the best odds for the Under at -110.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Rays (+1.5) are a 60% chance of covering the run line, while the 7-run Over/Under is a 56% chance of going Over.

More: Best Prop Bets to Make Today

Best Bets for Astros vs. Rays

• Run Line: Astros -1.5 @ +140 via BetMGM
• Moneyline: Astros @ -125 via BetMGM (55% probability)
• Total: Over 7 @ +100 via DraftKings Sportsbook (56% probability) 🔥

Every time you see a 🔥, that means you've found one of our best bets today across all major pro and college sports.

Our best bets are based on detailed modeling and gambling expertise to help you make more informed decisions with the legal sportsbooks in your state.

Even though the Rays are more likely to cover the run line, our best bet of Astros -1.5 is based on the likelihood of that happening, according to DimersBOT, and the top odds available.

Astros vs. Rays Betting Guide

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Dimers has full betting coverage of Wednesday's Astros-Rays matchup, including pregame predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so refresh this article for the latest betting analysis ahead of Astros vs. Rays on Wednesday September 21, 2022.

Astros vs. Rays 2022 Game Info

Wednesday's action between the Rays and Astros at Tropicana Field is scheduled to commence at 6:40PM ET.

• Who: Houston Astros vs. Tampa Bay Rays
• Date: Wednesday September 21, 2022
• Time: 6:40PM ET / 3:40PM PT
• Venue: Tropicana Field

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Finally, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds available.