Western Michigan vs. Buffalo prediction favors Western Michigan to win Week 5 MACtion clash

Buffalo will face the favored Western Michigan in Week 5 college football action at Broadview Stadium on Saturday, with kickoff at 1:00 PM ET.

Dimers' proven college football model projects Western Michigan as the most likely winner in this Western Michigan vs. Buffalo prediction.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Western Michigan vs. Buffalo prediction and odds

Using powerful machine learning and data, we have re-simulated the result of Western Michigan vs. Buffalo, forming part of our college football predictions coverage.

Our independent predictive model gives Western Michigan an 83.3% chance of beating Buffalo. Our predicted final score has Western Michigan winning 29-17. According to our model, Buffalo (+13) has a 50.9% chance of covering the spread, while the 45.5-point over/under has a 55.4% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Western Michigan -13 (-110) / Buffalo +13 (-110)
• Moneyline: Western Michigan -530, Buffalo +440
• Total: Over/Under 45.5 (-110/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Buffalo +13 @ -110 via Caesars
• Moneyline: Western Michigan @ -530 via Caesars
• Total: Over 45.5 @ -110 via bet365

According to our college football best bets, the top play to make on this game is Over 45.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Buffalo and Western Michigan at Broadview Stadium is scheduled to commence at 1:00 PM ET.

• Who: Western Michigan vs. Buffalo
• Date: Saturday, October 3, 2026
• Time: 1:00 PM ET/10:00AM PT
• Venue: Broadview Stadium

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Conclusion

We predict Western Michigan, with an 83.3% win probability, will likely beat Buffalo in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.