Vanderbilt vs. Mississippi State prediction: Why Mississippi State is favored to win in college football Week 10 [2026]

Using innovative machine learning and data, we have re-simulated the outcome of Vanderbilt vs. Mississippi State, forming part of our college football predictions coverage.

Our independent predictive model gives Mississippi State a 58.7% chance of beating Vanderbilt. Our predicted final score has Mississippi State winning 26-22. According to our model, Mississippi State (-2.5) has a 52.2% chance of covering the spread, while the 47.5-point over/under has a 55.5% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Vanderbilt +2.5 (+104) / Mississippi State -2.5 (-106)
• Moneyline: Vanderbilt +130, Mississippi State -133
• Total: Over/Under 47.5 (-115/-107)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Mississippi State -2.5 @ 51¢ via Novig
• Moneyline: Mississippi State @ 57¢ via Novig
• Total: Over 47.5 @ -115 via BetRivers

According to our best college football bets, the top play to make on this game is Over 47.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Mississippi State and Vanderbilt at Davis Wade Stadium at Scott Field is scheduled to start at 4:15 PM ET.

• Who: Vanderbilt vs. Mississippi State
• Date: Saturday, November 7, 2026
• Time: 4:15 PM ET/1:15 PM PT
• Venue: Davis Wade Stadium at Scott Field

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Conclusion

We predict Mississippi State, with a 58.7% win probability, will likely beat Vanderbilt in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary college football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.