South Dakota State vs. Northern Iowa prediction favors South Dakota State to win in college football Week 10 [2026]

Using innovative machine learning and data, we have re-simulated the result of South Dakota State vs. Northern Iowa, forming part of our college football predictions coverage.

Our leading predictive model gives South Dakota State an 84.7% chance of beating Northern Iowa. Our predicted final score has South Dakota State winning 32-18. According to our model, the oddsmakers have got it right, and South Dakota State and Northern Iowa each have a 50% chance of covering the spread, while the over/under total of 49.5 points has a 53.6% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: South Dakota State -14 (-118) / Northern Iowa +14 (-106)
• Moneyline: South Dakota State -525, Northern Iowa +471
• Total: Over/Under 49.5 (-110/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Northern Iowa +14 @ -106 via DraftKings
• Moneyline: South Dakota State @ 84¢ via Novig
• Total: Over 49.5 @ -110 via BetRivers

According to our college football best bets, the top play to make on this game is Over 49.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Northern Iowa and South Dakota State at UNI-Dome is scheduled to start at 2:00 PM ET.

• Who: South Dakota State vs. Northern Iowa
• Date: Saturday, November 7, 2026
• Time: 2:00 PM ET/11:00 AM PT
• Venue: UNI-Dome

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Conclusion

We predict South Dakota State, with an 84.7% win probability, will likely beat Northern Iowa in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary college football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.