Samford vs. East Tennessee State prediction: Why East Tennessee State is favored to win in college football Week 10 [2026]

Using trusted machine learning and statistical analysis, we have re-simulated the result of Samford vs. East Tennessee State, forming part of our college football predictions coverage.

Our leading predictive model gives East Tennessee State an 85.8% chance of defeating Samford. Our predicted final score has East Tennessee State winning 30-16. According to our model, East Tennessee State (-12.5) has a 52.1% chance of covering the spread, while the over/under total of 46.5 points has a 53.2% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Samford +12.5 (-110) / East Tennessee State -12.5 (-112)
• Moneyline: Samford +456, East Tennessee State -488
• Total: Over/Under 46.5 (-110/-108)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: East Tennessee State -12.5 @ -112 via DraftKings
• Moneyline: East Tennessee State @ 83¢ via Novig
• Total: Over 46.5 @ -110 via bet365

According to our best college football bets, the top play to make on this game is East Tennessee State to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between East Tennessee State and Samford at William B. Greene Jr. Stadium is scheduled to start at 1:00 PM ET.

• Who: Samford vs. East Tennessee State
• Date: Saturday, November 7, 2026
• Time: 1:00 PM ET/10:00 AM PT
• Venue: William B. Greene Jr. Stadium

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Conclusion

We predict East Tennessee State, with an 85.8% win probability, will likely beat Samford in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary college football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.