Oregon vs. Southern California prediction favors Oregon to win in college football Week 4 [2026]

Using powerful machine learning and data analysis, we have re-simulated the outcome of Oregon vs. Southern California, forming part of our college football predictions coverage.

Our independent predictive model currently gives Oregon a 62.6% chance of beating Southern California. Our predicted final score has Oregon winning 32-28. According to our model, Oregon (-3.5) has a 51.1% chance of covering the spread, while the 61.5-point over/under has a 51.5% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Oregon -3.5 (+100) / Southern California +3.5 (-114)
• Moneyline: Oregon -170, Southern California +145
• Total: Over/Under 61.5 (-110/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Oregon -3.5 @ +100 via bet365
• Moneyline: Oregon @ -170 via bet365
• Total: Under 61.5 @ -106 via Caesars

According to our college football best bets, the top play to make on this game is Oregon -3.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Southern California and Oregon at Los Angeles Memorial Coliseum is scheduled to commence at 7:30 PM ET.

• Who: Oregon vs. Southern California
• Date: Saturday, September 26, 2026
• Time: 7:30 PM ET/4:30PM PT
• Venue: Los Angeles Memorial Coliseum

College football Week 4 promos

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Conclusion

We predict Oregon, with a 62.6% win probability, will likely beat Southern California in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.