Holy Cross vs. Lafayette prediction favors Lafayette to win in college football Week 4 [2026]

Using trusted machine learning and data analysis, we have re-simulated the result of Holy Cross vs. Lafayette, forming part of our college football predictions coverage.

Our famous predictive model gives Lafayette a 65.9% chance of beating Holy Cross. Our predicted final score has Lafayette winning 27-22. According to our model, Holy Cross (+5.5) has a 51.3% chance of covering the spread, while the over/under total of 47.5 points has a 55.4% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Holy Cross +5.5 (-107) / Lafayette -5.5 (-115)
• Moneyline: Holy Cross +170, Lafayette -213
• Total: Over/Under 47.5 (-115/-103)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Holy Cross +5.5 @ -107 via DraftKings
• Moneyline: Lafayette @ -213 via DraftKings
• Total: Over 47.5 @ -115 via bet365

According to our college football best bets, the top play to make on this game is Over 47.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between Lafayette and Holy Cross at Fisher Stadium is scheduled to start at 12:30 PM ET.

• Who: Holy Cross vs. Lafayette
• Date: Saturday, September 26, 2026
• Time: 12:30 PM ET/9:30AM PT
• Venue: Fisher Stadium

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Conclusion

We predict Lafayette, with a 65.9% win probability, will likely beat Holy Cross in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.