Eastern Illinois vs. South Dakota State prediction favors South Dakota State to win in college football Week 4 [2026]

Using trusted machine learning and data, we have re-simulated the result of Eastern Illinois vs. South Dakota State, forming part of our college football predictions coverage.

Our independent predictive model currently gives South Dakota State a 98.7% chance of defeating Eastern Illinois. Our predicted final score has South Dakota State winning 44-9. According to our model, South Dakota State (-34.5) has a 51.3% chance of covering the spread, while the over/under total of 53.5 points has a 51.4% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Eastern Illinois +34.5 (-111) / South Dakota State -34.5 (-111)
• Moneyline: Eastern Illinois , South Dakota State

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Over @ -115 via Bet365

According to our best college football bets, the top play to make on this game is South Dakota State -34.5.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football action between South Dakota State and Eastern Illinois at Dana J. Dykhouse Stadium is scheduled to begin at 7:00 PM ET.

• Who: Eastern Illinois vs. South Dakota State
• Date: Saturday, September 26, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Dana J. Dykhouse Stadium

College football Week 4 promos

Make the most of Dimers' Eastern Illinois vs. South Dakota State predictions by exploring the Bet365 Sportsbook offer below:

Conclusion

We predict South Dakota State, with a 98.7% win probability, will likely beat Eastern Illinois in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.