NFL picks straight up: Week 3, 2026

At Dimers, our Week 3 NFL picks are grounded in data-driven insight, with straight-up picks for all 16 games informed by our latest NFL predictions.

Get an edge in your NFL pick 'em contests with our data-driven NFL Week 3 picks straight up, powered by thousands of game simulations.

Week 3 of the NFL season begins with the Atlanta Falcons facing the Green Bay Packers on Thursday night and concludes with the Philadelphia Eagles taking on the Chicago Bears on Monday night.

NFL picks this week straight up: Week 3, 2026

Here are our Week 3 NFL picks highlighting how likely each team is to win their game this week.

Atlanta Falcons vs. Green Bay Packers

The Falcons kick off Week 3 against the Packers at Lambeau Field on Thursday night. According to our model, the Packers have a 71% chance of winning, while the Falcons have a 29% chance.

For Week 3's opening game, our model highlights NFL player projections, with Bijan Robinson (RB) the most likely player from the Falcons to score the first TD at 13.2%, while Christian Watson (WR) is the top candidate from the Packers at 14.2%.

Check out our full Atlanta Falcons vs. Green Bay Packers prediction ahead of this week's matchup at Lambeau Field, set for Thursday, September 24 at 8:15pm. All times mentioned in this article are in Eastern Standard Time (EST).

Kansas City Chiefs vs. Miami Dolphins

For this week's game between the Chiefs and the Dolphins, Kansas City is more likely to win. Our prediction model gives the Chiefs an 82% chance of winning. On the other hand, there is an 18% chance that the Dolphins will pull off an upset win.

Explore the latest data in this week's Kansas City Chiefs vs. Miami Dolphins prediction before kickoff in Miamion Sunday at 1:00pm.

As the season heats up, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Carolina Panthers vs. Cleveland Browns

We are picking the Panthers to win their game against the Browns this week, with our powerful NFL model projecting a 60% win probability for the road team. The Browns have a 40% chance of winning at Huntington Bank Field.

For betting purposes, the Browns are listed as +2.5 underdogs, with the Panthers' moneyline at -145.

Find the complete Carolina Panthers vs. Cleveland Browns prediction for a closer look at Sunday's 1:00pm game.

Tennessee Titans vs. New York Giants

According to our predictive analytics model, the Giants are the team to beat in this game, with their win probability at 64%. The Titans, on the other hand, have a 36% chance of winning.

Review the edges and numbers in our Tennessee Titans vs. New York Giants prediction for this Sunday 1:00pm clash at MetLife Stadium.

New England Patriots vs. Jacksonville Jaguars

The Jaguars have a 61% chance of winning on Sunday afternoon, compared to the Patriots' 39% chance of victory. This makes the Jacksonville Jaguars our pick to win at EverBank Stadium.

See the numbers behind this matchup in the full New England Patriots vs. Jacksonville Jaguars prediction scheduled for Sunday at 1:00pm at EverBank Stadium.

Los Angeles Chargers vs. Buffalo Bills

The Bills are favorites to win their game this week, with our model giving them a 75% chance, while the Chargers enter the weekend with a 25% chance of causing an upset at Highmark Stadium.

When it comes to betting on this game, the Chargers' moneyline odds are set at +300, with the home team Bills listed as -7 favorites.

This week's Los Angeles Chargers vs. Buffalo Bills prediction highlights the top values for the game at Highmark Stadium on Sunday, September 27 at 1:00pm.

New York Jets vs. Detroit Lions

After 10,000 simulations of Jets vs. Lions this Sunday, our model projects the Lions as the more likely winners with a probability of 72%. Their opponents, the Jets, have a 28% chance of getting the win on the road.

Compare projections and odds for this matchup in our New York Jets vs. Detroit Lions prediction, set for Sunday at 1:00pm.

Houston Texans vs. Indianapolis Colts

DimersBOT is picking the Texans, who have a 57% chance of winning the game, while the Colts have a 43% win probability.

Access the full data breakdown in our Houston Texans vs. Indianapolis Colts prediction ahead of kickoff at Lucas Oil Stadium.

Seattle Seahawks vs. Washington Commanders

The next game of Week 3 sees the Seahawks take on the Commanders at Northwest Stadium.

We predict the Seahawks to win with a probability of 68%, while the Commanders are projected to have a win chance of 32%.

As for the Vegas betting odds here, the Commanders are listed as +7 underdogs, with the Seahawks' moneyline odds posted at -305.

Breakdown further probabilities and player projections in the Seattle Seahawks vs. Washington Commanders prediction for Sunday, September 27 at 1:00pm.

Cincinnati Bengals vs. Pittsburgh Steelers

The likely winner of this matchup is the Bengals, who have a projected win chance of 64%, according to DimersBOT. On the other side of this matchup, the Steelers have a projected win probability of 36%.

Check out our Cincinnati Bengals vs. Pittsburgh Steelers prediction to see where the rest of the numbers lean ahead of Sunday's game in Pittsburgh.

Arizona Cardinals vs. San Francisco 49ers

We have run our powerful NFL model over this week’s Cardinals-49ers clash 10,000 times, with the 49ers coming out as the team to pick. Of those 10,000 simulations, the 49ers won 7,689 times, with the Cardinals winning on 2,311 occasions.

Get direct access to more game projections with our Arizona Cardinals vs. San Francisco 49ers prediction before Sunday's clash at Levi's Stadium

Minnesota Vikings vs. Tampa Bay Buccaneers

Next up is the game between the Vikings and Buccaneers, with our model projecting the road team as the more likely victor, with the Vikings rated as having a 57% chance of getting the W. The Buccaneers, on the other hand, are projected to have a 43% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Vikings' moneyline odds set at -120 for this road game, while the hosting Buccaneers are listed as +1.5 underdogs.

Examine further probabilities in the full Minnesota Vikings vs. Tampa Bay Buccaneers prediction, scheduled for Sunday at 4:05pm.

Las Vegas Raiders vs. New Orleans Saints

Our next straight up pick this week is for the Saints to get the win against the Raiders. After running 10,000 simulations of this matchup, the New Orleans have a win probability of 64%, with the Raiders at 36%.

View the complete Las Vegas Raiders vs. New Orleans Saints prediction for a deeper look at this Sunday's game in New Orleans.

Baltimore Ravens vs. Dallas Cowboys

With a win probability of 61% on Sunday afternoon, our straight up pick for this matchup is the Ravens, while their opponent, the Cowboys, have a projected win chance of 39%.

Check out the latest projections in this week's Baltimore Ravens vs. Dallas Cowboys prediction before kickoff on Sunday, September 27 at 4:25pm.

Los Angeles Rams vs. Denver Broncos

The team to pick here is the Rams, who have a 61% chance of winning their matchup against the Broncos this Sunday night.

Looking at the betting odds for this Sunday Night Football clash, the Broncos are listed as +2.5 underdogs at home, with the Rams' moneyline odds available at -135.

Find all game probabilities and odds in the full Los Angeles Rams vs. Denver Broncos prediction for Sunday's matchup at Empower Field at Mile High.

Philadelphia Eagles vs. Chicago Bears

Our pick to win the final game of Week 3 is the Eagles, who have a win probability of 62%. Their opponents are projected to have a 38% chance of getting the W.

See where the projections identify value in our Philadelphia Eagles vs. Chicago Bears prediction, set for Monday at 8:15pm at Soldier Field.

Full list of NFL Week 3 picks straight up

This week's most likely NFL winners, ordered by probability:

• Chiefs 81.9% @ Dolphins
• 49ers (76.9)% vs. Cardinals
• Bills (74.9)% vs. Chargers
• Lions (72.1)% vs. Jets
• Packers (71.5)% vs. Falcons
• Seahawks 68.5% @ Commanders
• Bengals 64.4% @ Steelers
• Giants (64.3)% vs. Titans
• Saints (64.1)% vs. Raiders
• Eagles 62.3% @ Bears
• Ravens 61.5% @ Cowboys
• Rams 61.1% @ Broncos
• Jaguars (60.7)% vs. Patriots
• Panthers 60.2% @ Browns
• Vikings 57.0% @ Buccaneers
• Texans 56.8% @ Colts

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NFL straight up picks and predictions for Week 3

The NFL Week 3 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.