Tampa Bay Buccaneers vs. Carolina Panthers: Experts release early Week 16 projections [2025]

The Tampa Bay Buccaneers and Carolina Panthers will meet in Week 16 of the NFL season at Bank of America Stadium on Sunday, December 21, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Buccaneers as the most likely winner of this NFC South rivalry matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Buccaneers vs. Panthers predictions page.

Tampa Bay vs. Carolina early predictions

Leveraging trusted machine learning and analysis, we have simulated the Bucs vs. Panthers game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Buccaneers 59%, Panthers 41%
• Predicted final score: Buccaneers 23-21 Panthers
• Spread: Buccaneers (-1.5) 53%, Panthers (+1.5) 47%
• Total points (45.5): Over 45%, Under 55%

As of December 15, 2025, these Buccaneers-Panthers numbers and predictions reflect the latest data and insights available.

Bucs vs. Panthers Week 16 details

The NFL Week 16 game between the Panthers and Buccaneers at Bank of America Stadium is scheduled for December 21, 2025.

• Who: Tampa Bay Buccaneers vs. Carolina Panthers
• Date: Sunday, December 21, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Bank of America Stadium

Bucs vs. Panthers opening odds

We've researched the best betting odds across America for this Week 16 game, which are listed here:

• Spread: Buccaneers -1.5 (-110), Panthers +1.5 (-110)
• Moneyline: Buccaneers -125, Panthers +116
• Total: Over/Under 45.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Buccaneers, with a 59% win probability, will likely beat the Panthers in Week 16 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Buccaneers vs. Panthers game, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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