Pittsburgh Steelers vs. Detroit Lions: Experts release early Week 16 predictions [2025]

The Pittsburgh Steelers and Detroit Lions will meet in Week 16 of the NFL season at Ford Field on Sunday, December 21, 2025, starting at 4:25PM ET.

Initial simulations from Dimers' trusted NFL model favor the Lions as the most likely winner of this cross-conference meeting.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Steelers vs. Lions predictions page.

Pittsburgh vs. Detroit early predictions

Leveraging trusted machine learning and analysis, we have simulated the Steelers vs. Lions game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Steelers 28%, Lions 72%
• Predicted final score: Steelers 21-28 Lions
• Spread: Steelers (+6.5) 50%, Lions (-6.5) 50%
• Total points (49.5): Over 50%, Under 50%

As of December 15, 2025, these Steelers-Lions figures and predictions reflect the latest data and insights available.

Steelers vs. Lions Week 16 details

The NFL Week 16 matchup between the Lions and Steelers at Ford Field is scheduled for December 21, 2025.

• Who: Pittsburgh Steelers vs. Detroit Lions
• Date: Sunday, December 21, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: Ford Field

Steelers vs. Lions opening odds

We've researched the best betting odds across America for this Week 16 game, which are listed here:

• Spread: Steelers +6.5 (-110), Lions -6.5 (-105)
• Moneyline: Steelers +245, Lions -285
• Total: Over/Under 49.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Lions, with a 72% win probability, will likely beat the Steelers in Week 16 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Steelers vs. Lions game, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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