Philadelphia Eagles vs. Buffalo Bills: Experts release early Week 17 preview [2025]

The Philadelphia Eagles and Buffalo Bills will meet in Week 17 of the NFL season at Highmark Stadium on Sunday, December 28, 2025, starting at 4:25 PM ET.

Early simulations from Dimers' trusted NFL model favor the Bills as the most likely winner of this cross-conference meeting.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Eagles vs. Bills predictions page.

Philadelphia vs. Buffalo early predictions

Leveraging trusted machine learning and analysis, we have simulated the Eagles vs. Bills game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Eagles 39%, Bills 61%
• Predicted final score: Eagles 21-24 Bills
• Spread: Eagles (+3) 50%, Bills (-3) 50%
• Total points (44.5): Over 54%, Under 46%

As of December 22, 2025, these Eagles-Bills numbers and predictions reflect the latest data and insights available.

Eagles vs. Bills Week 17 details

The NFL Week 17 game between the Bills and Eagles at Highmark Stadium is scheduled for December 28, 2025.

• Who: Philadelphia Eagles vs. Buffalo Bills
• Date: Sunday, December 28, 2025
• Time: 4:25 PM ET/1:25PM PT
• Venue: Highmark Stadium

Eagles vs. Bills opening odds

We've researched the best betting odds across America for this Week 17 game, which are listed here:

• Spread: Eagles +3 (-110), Bills -3 (-105)
• Moneyline: Eagles +136, Bills -155
• Total: Over/Under 44.5 (-115/-105)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Bills, with a 61% win probability, will likely beat the Eagles in Week 17 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Eagles vs. Bills game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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