New Orleans Saints vs. Tennessee Titans: Experts release early Week 17 predictions [2025]

The New Orleans Saints and Tennessee Titans will meet in Week 17 of the NFL season at Nissan Stadium on Sunday, December 28, 2025, starting at 1:00 PM ET.

Early simulations from Dimers' trusted NFL model favor the Saints as the most likely winner of this cross-conference battle.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Saints vs. Titans predictions page.

New Orleans vs. Tennessee early predictions

Leveraging trusted machine learning and analysis, we have simulated the Saints vs. Titans game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Saints 60%, Titans 40%
• Predicted final score: Saints 20-18 Titans
• Spread: Saints (-1.5) 53%, Titans (+1.5) 47%
• Total points (39.5): Over 47%, Under 53%

As of December 22, 2025, these Saints-Titans figures and predictions reflect the latest data and insights available.

Saints vs. Titans Week 17 details

The NFL Week 17 action between the Titans and Saints at Nissan Stadium is scheduled for December 28, 2025.

• Who: New Orleans Saints vs. Tennessee Titans
• Date: Sunday, December 28, 2025
• Time: 1:00 PM ET/10:00AM PT
• Venue: Nissan Stadium

Saints vs. Titans opening odds

We've researched the best betting odds across America for this Week 17 game, which are listed here:

• Spread: Saints -1.5 (-110), Titans +1.5 (-110)
• Moneyline: Saints -125, Titans +118
• Total: Over/Under 39.5 (-105/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Saints, with a 60% win probability, will likely beat the Titans in Week 17 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Saints vs. Titans matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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