MLS Betting Tips: Saturday's Picks Include Portland vs. San Jose Play [5/3/2025]

MLS betting is back for another enticing day on 5/3, and we're here to bring you our top picks for Saturday's soccer action.

Today's MLS best bets come from a range of matchups, including Portland vs. San Jose and St Louis City vs. Seattle, with this article updated throughout the day to highlight the most attractive upcoming games.

Led by a standout moneyline play at 10:30PM ET, these picks are based on advanced simulations and machine learning.

For unlimited access to everything Dimers has to offer on Saturday, May 3, 2025—including our complete set of MLS picks and best bets—check out Dimers Pro.

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List of MLS Betting Tips Tonight [5/3, Updated: 10:01PM ET]

After digging deep into the numbers and running thousands of simulations, our leading predictive analytics model has identified the best soccer bets for Saturday, May 3, 2025.

We sort these picks by start times, reserving the highest edges and probabilities exclusively for Dimers Pro subscribers.

Portland ML (+255)

• Edge: 5.8%
• Probability: 34%
• Matchup: Portland vs. San Jose (10:30PM ET, Saturday)

Our model has pinpointed the next MLS betting opportunity tonight, which comes in the Portland vs. San Jose game. We recommend a bet on the Portland ML at +255 odds, offering an edge of 5.8%.

Portland ML vs. San Jose

+255

Bet $25
Payout $88.75Bet $25, Payout $88.75

St Louis City vs. Seattle Under 2.5 Goals (+106)

• Edge: 4.8%
• Probability: 53.3%
• Matchup: St Louis City vs. Seattle (10:30PM ET, Saturday)

Our model has found another great MLS bet for Saturday's soccer action, this time in the game between St Louis City and Seattle. We suggest placing an over/under wager on Under 2.5 Goals at +106 odds, with our analysis showing a compelling 4.8% edge.

St Louis City vs. Seattle Under 2.5 Goals

+106

Bet $25
Payout $51.50Bet $25, Payout $51.50

MORE: Saturday's Player Prop Picks

MLS Best Bets: Saturday, 5/3/2025

As of 10:01PM ET, here are the next two MLS bets recommended by our model:

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While the bets listed are all positive expected value (+EV) opportunities, subscribing to Dimers Pro grants you unlimited access to today's best bets across all sports, powered by our advanced model.

Join Dimers Pro now to access these picks, along with a comprehensive range of props, trends and parlays for May 3, 2025.

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List of Upcoming MLS Games to Bet On [5/3/2025]

• Portland vs. San Jose (10:30PM ET, Saturday)
• Houston vs. LAFC (10:30PM ET, Saturday)
• St Louis City vs. Seattle (10:30PM ET, Saturday)
• Cincinnati vs. NY City (3:00PM ET, Sunday)
• LA Galaxy vs. Sporting KC (7:00PM ET, Sunday)

More on MLS

This article is part of our MLS best bets series.

For more MLS betting content, we have MLS betting news and the latest MLS Cup odds and predictions.

Conclusion

This article, enhanced by AI and automation, aims to deliver accurate MLS insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.