Indianapolis Colts vs. Seattle Seahawks: Experts release early Week 15 predictions [2025]

The Indianapolis Colts and Seattle Seahawks will meet in Week 15 of the NFL season at Lumen Field on Sunday, December 14, 2025, starting at 4:25PM ET.

Early simulations from Dimers' trusted NFL model favor the Seahawks as the most likely winner of this cross-conference meeting.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Colts vs. Seahawks predictions page.

Indianapolis vs. Seattle early predictions

Leveraging trusted machine learning and analysis, we have simulated the Colts vs. Seahawks game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Colts 39%, Seahawks 61%
• Predicted final score: Colts 21-25 Seahawks
• Spread: Colts (+3.5) 50%, Seahawks (-3.5) 50%
• Total points (46.5): Over 50%, Under 50%

As of December 8, 2025, these Colts-Seahawks figures and predictions reflect the latest data and insights available.

Colts vs. Seahawks Week 15 details

The NFL Week 15 action between the Seahawks and Colts at Lumen Field is scheduled for December 14, 2025.

• Who: Indianapolis Colts vs. Seattle Seahawks
• Date: Sunday, December 14, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: Lumen Field

Colts vs. Seahawks opening odds

We've researched the best betting odds across America for this Week 15 game, which are listed here:

• Spread: Colts +3.5 (-105), Seahawks -3.5 (-110)
• Moneyline: Colts +168, Seahawks -185
• Total: Over/Under 46.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Seahawks, with a 61% win probability, will likely beat the Colts in Week 15 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Colts vs. Seahawks matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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