Indianapolis Colts vs. Los Angeles Chargers: Experts release early Week 7 preview [2025]

The Indianapolis Colts and Los Angeles Chargers will meet in Week 7 of the NFL season at SoFi Stadium on Sunday, October 19, 2025, starting at 4:05PM ET.

Early simulations from Dimers' trusted NFL model favor the Chargers as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Colts vs. Chargers predictions page.

Indianapolis vs. LA Chargers early predictions

Leveraging trusted machine learning and analysis, we have simulated the Colts vs. Chargers game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Colts 29%, Chargers 71%
• Predicted final score: Colts 19-25 Chargers
• Spread: Colts (+6) 50%, Chargers (-6) 50%
• Total points (45.5): Over 50%, Under 50%

As of October 12, 2025, these Colts-Chargers calculations and predictions reflect the latest data and insights available.

Colts vs. Chargers Week 7 details

The NFL Week 7 action between the Chargers and Colts at SoFi Stadium is scheduled for October 19, 2025.

• Who: Indianapolis Colts vs. Los Angeles Chargers
• Date: Sunday, October 19, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: SoFi Stadium

Colts vs. Chargers opening odds

We've researched the best betting odds across America for this Week 7 game, which are listed here:

• Spread: Colts +6 (-110), Chargers -6 (-110)
• Moneyline: Colts +210, Chargers -258
• Total: Over/Under 45.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Chargers, with a 71% win probability, will likely beat the Colts in Week 7 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Colts vs. Chargers game, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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