Detroit Lions vs. Los Angeles Rams: Experts release early Week 15 predictions [2025]

The Detroit Lions and Los Angeles Rams will meet in Week 15 of the NFL season at SoFi Stadium on Sunday, December 14, 2025, starting at 4:25PM ET.

Initial simulations from Dimers' trusted NFL model favor the Rams as the most likely winner of this NFC clash.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Lions vs. Rams predictions page.

Detroit vs. LA Rams early predictions

Leveraging trusted machine learning and analysis, we have simulated the Lions vs. Rams game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Lions 34%, Rams 66%
• Predicted final score: Lions 22-27 Rams
• Spread: Lions (+4.5) 50%, Rams (-4.5) 50%
• Total points (50.5): Over 50%, Under 50%

As of December 8, 2025, these Lions-Rams calculations and predictions reflect the latest data and insights available.

Lions vs. Rams Week 15 details

The NFL Week 15 game between the Rams and Lions at SoFi Stadium is scheduled for December 14, 2025.

• Who: Detroit Lions vs. Los Angeles Rams
• Date: Sunday, December 14, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: SoFi Stadium

Lions vs. Rams opening odds

We've researched the best betting odds across America for this Week 15 game, which are listed here:

• Spread: Lions +4.5 (-110), Rams -4.5 (-106)
• Moneyline: Lions +180, Rams -205
• Total: Over/Under 50.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Rams, with a 66% win probability, will likely beat the Lions in Week 15 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Lions vs. Rams game, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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