Chicago Bears vs. San Francisco 49ers: Experts release early Week 17 predictions [2025]

The Chicago Bears and San Francisco 49ers will meet in Week 17 of the NFL season at Levi's Stadium on Sunday, December 28, 2025, starting at 8:20 PM ET.

Initial simulations from Dimers' trusted NFL model favor the 49ers as the most likely winner of this NFC clash.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Bears vs. 49ers predictions page.

Chicago vs. San Francisco early predictions

Leveraging trusted machine learning and analysis, we have simulated the Bears vs. Niners game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Bears 40%, 49ers 60%
• Predicted final score: Bears 23-26 49ers
• Spread: Bears (+2.5) 44%, 49ers (-2.5) 56%
• Total points (51.5): Over 44%, Under 56%

As of December 22, 2025, these Bears-49ers numbers and predictions reflect the latest data and insights available.

Bears vs. Niners Week 17 details

The NFL Week 17 game between the 49ers and Bears at Levi's Stadium is scheduled for December 28, 2025.

• Who: Chicago Bears vs. San Francisco 49ers
• Date: Sunday, December 28, 2025
• Time: 8:20 PM ET/5:20PM PT
• Venue: Levi's Stadium

Bears vs. Niners opening odds

We've researched the best betting odds across America for this Week 17 game, which are listed here:

• Spread: Bears +2.5 (-105), 49ers -2.5 (-115)
• Moneyline: Bears +136, 49ers -144
• Total: Over/Under 51.5 (-105/-115)

Odds may continue to move—track live changes via our NFL odds page.

NFL Week 17 betting promos and codes

Make the most of Dimers' Bears vs. 49ers predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.

Conclusion

We predict the 49ers, with a 60% win probability, will likely beat the Bears in Week 17 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bears vs. 49ers game, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay informed with the latest NFL betting news and data-driven parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.