Chicago Bears vs. San Francisco 49ers: Experts release early Week 17 preview [2025]

The Chicago Bears and San Francisco 49ers will meet in Week 17 of the NFL season at Levi's Stadium on Sunday, December 28, 2025, starting at 8:20 PM ET.

Initial simulations from Dimers' trusted NFL model favor the 49ers as the most likely winner of this NFC matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Bears vs. 49ers predictions page.

Chicago vs. San Francisco early predictions

Leveraging trusted machine learning and analysis, we have simulated the Bears vs. Niners game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Bears 41%, 49ers 59%
• Predicted final score: Bears 23-26 49ers
• Spread: Bears (+2.5) 50%, 49ers (-2.5) 50%
• Total points (50.5): Over 50%, Under 50%

As of December 22, 2025, these Bears-49ers calculations and predictions reflect the latest data and insights available.

Bears vs. Niners Week 17 details

The NFL Week 17 action between the 49ers and Bears at Levi's Stadium is scheduled for December 28, 2025.

• Who: Chicago Bears vs. San Francisco 49ers
• Date: Sunday, December 28, 2025
• Time: 8:20 PM ET/5:20PM PT
• Venue: Levi's Stadium

Bears vs. Niners opening odds

We've researched the best betting odds across America for this Week 17 game, which are listed here:

• Spread: Bears +2.5 (-104), 49ers -2.5 (-118)
• Moneyline: Bears +128, 49ers -148
• Total: Over/Under 50.5 (-105/-110)

Odds may continue to move—track live changes via our NFL odds page.

Anytime touchdown scorer predictions

Early NFL player projections for Week 17 highlight the top candidates to score a TD in Bears-Niners in Week 17:

Chicago Bears

• D'Andre Swift: 41.2% probability
• Kyle Monangai: 37.3% probability
• DJ Moore: 31.5% probability

San Francisco 49ers

• Christian McCaffrey: 68.7% probability
• George Kittle: 40.9% probability
• Jauan Jennings: 39.8% probability

Bears vs 49ers player props

D'Andre Swift is projected to lead rushing for the Bears, while Christian McCaffrey is expected to pace the 49ers on the ground.

In the receiving game, our projections favor Chicago's DJ Moore and San Francisco's Jauan Jennings as the likely leaders for each team.

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Conclusion

We predict the 49ers, with a 59% win probability, will likely beat the Bears in Week 17 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bears vs. 49ers game, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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