Carolina Panthers vs. New Orleans Saints: Experts release early Week 15 predictions [2025]

The Carolina Panthers and New Orleans Saints will meet in Week 15 of the NFL season at Caesars Superdome on Sunday, December 14, 2025, starting at 4:25PM ET.

Early simulations from Dimers' trusted NFL model favor the Panthers as the most likely winner of this NFC South rivalry matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Panthers vs. Saints predictions page.

Carolina vs. New Orleans early predictions

Leveraging trusted machine learning and analysis, we have simulated the Panthers vs. Saints game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Panthers 60%, Saints 40%
• Predicted final score: Panthers 20-18 Saints
• Spread: Panthers (-2.5) 50%, Saints (+2.5) 50%
• Total points (38.5): Over 52%, Under 48%

As of December 8, 2025, these Panthers-Saints calculations and predictions reflect the latest data and insights available.

Panthers vs. Saints Week 15 details

The NFL Week 15 matchup between the Saints and Panthers at Caesars Superdome is scheduled for December 14, 2025.

• Who: Carolina Panthers vs. New Orleans Saints
• Date: Sunday, December 14, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: Caesars Superdome

Panthers vs. Saints opening odds

We've researched the best betting odds across America for this Week 15 game, which are listed here:

• Spread: Panthers -2.5 (-118), Saints +2.5 (-102)
• Moneyline: Panthers -146, Saints +124
• Total: Over/Under 38.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Panthers, with a 60% win probability, will likely beat the Saints in Week 15 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Panthers vs. Saints game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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