Carolina Panthers vs. Arizona Cardinals early prediction: Expert picks for NFL Week 2, 2025

The Carolina Panthers and Arizona Cardinals will meet in Week 2 of the NFL season at State Farm Stadium on Sunday, September 14, 2025, starting at 4:05PM ET.

Initial simulations from Dimers' trusted NFL model favor the Cardinals as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Panthers vs. Cardinals predictions page.

Carolina vs. Arizona early predictions

Leveraging trusted machine learning and analysis, we have simulated the Panthers vs. Cardinals game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Panthers 35%, Cardinals 65%
• Predicted final score: Panthers 20-24 Cardinals
• Spread: Panthers (+4.5) 50%, Cardinals (-4.5) 50%
• Total points (46.5): Over 47%, Under 53%

As of September 7, 2025, these Panthers-Cardinals numbers and predictions reflect the latest data and insights available.

Panthers vs. Cardinals Week 2 details

The NFL Week 2 game between the Cardinals and Panthers at State Farm Stadium is scheduled for September 14, 2025.

• Who: Carolina Panthers vs. Arizona Cardinals
• Date: Sunday, September 14, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: State Farm Stadium

Panthers vs. Cardinals opening odds

We've researched the best betting odds across America for this Week 2 game, which are listed here:

• Spread: Panthers +4.5 (-110), Cardinals -4.5 (-110)
• Moneyline: Panthers +180, Cardinals -218
• Total: Over/Under 46.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Cardinals, with a 65% win probability, will likely beat the Panthers in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Panthers vs. Cardinals matchup, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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