Atlanta Falcons vs. Arizona Cardinals: Experts release early Week 16 predictions [2025]

The Atlanta Falcons and Arizona Cardinals will meet in Week 16 of the NFL season at State Farm Stadium on Sunday, December 21, 2025, starting at 4:05PM ET.

Early simulations from Dimers' trusted NFL model favor the Cardinals as the most likely winner of this NFC showdown.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Falcons vs. Cardinals predictions page.

Atlanta vs. Arizona early predictions

Leveraging trusted machine learning and analysis, we have simulated the Falcons vs. Cardinals game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Falcons 43%, Cardinals 57%
• Predicted final score: Falcons 21-23 Cardinals
• Spread: Falcons (+1.5) 50%, Cardinals (-1.5) 50%
• Total points (44.5): Over 53%, Under 47%

As of December 15, 2025, these Falcons-Cardinals numbers and predictions reflect the latest data and insights available.

Falcons vs. Cardinals Week 16 details

The NFL Week 16 matchup between the Cardinals and Falcons at State Farm Stadium is scheduled for December 21, 2025.

• Who: Atlanta Falcons vs. Arizona Cardinals
• Date: Sunday, December 21, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: State Farm Stadium

Falcons vs. Cardinals opening odds

We've researched the best betting odds across America for this Week 16 game, which are listed here:

• Spread: Falcons +1.5 (-104), Cardinals -1.5 (-105)
• Moneyline: Falcons +112, Cardinals -120
• Total: Over/Under 44.5 (-106/-114)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Cardinals, with a 57% win probability, will likely beat the Falcons in Week 16 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Falcons vs. Cardinals matchup, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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