Cardinals vs. Pirates: MLB Prediction & Analysis

Our detailed prediction and analysis for the Cardinals vs. Pirates MLB game on Wednesday, September 23, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
FINAL
MLB
FINAL
MLB sport icon
MLB
Cardinals
Matthew Liberatore 5-14, 5.36 ERA
5
1
PNC Park
Pirates
Lake Bachar 1-4, 3.56 ERA
PNC Park
1 2 3 4 5 6 7 8 9 RHE
Cardinals
0 0 3 2 0 0 0 0 0 5 10 0
Pirates
0 1 0 0 0 0 0 0 0 1 6 0
Live Probabilities
Win %
  • Cardinals
    100%
  • Pirates
    0%
Win Probability
Baseball infield diamond diagram
Last At Bat
Outs
Ronny Simon strikes out swinging.
Quick Box Score
Cardinals Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 J. Wetherholt 2B4131011.7501.550
2 I. Herrera DH3100010.0000.400
3 A. Burleson 1B5111003.2000.400
4 J. Walker RF4010001.2500.500
5 L. Bernal C4011001.2500.500
6 N. Gorman 3B3010011.3330.833
7 V. Scott LF0000000.0000.000
8 N. Church CF4000000.0000.000
9 M. Winn SS3111012.3331.167
Pirates Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 K. Griffin SS4000000.0000.000
2 R. Flores C4000001.0000.000
3 B. Reynolds LF3000011.0000.250
4 B. Lowe 2B4121101.5001.750
5 N. Gonzales DH4010001.2500.500
6 R. Simon RF4000002.0000.000
7 R. O'Hearn 1B3020000.6672.000
8 J. Triolo 3B3010001.3330.666
9 J. Mangum CF3000002.0000.000

Cardinals vs. Pirates: Detailed Breakdown

Matchup overview: MLB Wednesday

  • Teams: St. Louis Cardinals vs. Pittsburgh Pirates
  • Date: Wednesday, September 23, 2026
  • Time: 6:40PM ET
  • Venue: PNC Park

Current betting odds

  • Spread: Cardinals (+1.5, -174), Pirates (-1.5, +170)
  • Moneyline: Cardinals +127, Pirates -127
  • Total (Over/Under): 7.5 runs (+106/-108)

Dimers’ win probabilities

  • Cardinals: 43.0%
  • Pirates: 57.0%

Dimers' predictive MLB model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Cardinals a win probability of 43.0%, while the Pirates have a win probability of 57.0%.

Summary

According to our analysis, the Pirates are more likely to beat the Cardinals in the MLB game at PNC Park on Wednesday. Discover the best run line, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Cardinals vs. Pirates predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.