MLB picks today: Saturday's MLB best bets include Blue Jays vs. Yankees play [8/22/2026]

Blue Jays vs. Yankees Over 7 runs (+105)

• Edge: 8.1%
• Probability: 56.9%
• Matchup: Blue Jays vs. Yankees (1:35PM ET)

Our model has identified value on Over 7 runs in Blue Jays vs. Yankees at +105 odds. A 56.9% probability produces an edge of 8.1%, making this the strongest play for today's MLB slate.

Giants vs. Red Sox Over 8.5 runs (+115)

• Edge: 7.4%
• Probability: 53.9%
• Matchup: Giants vs. Red Sox (7:15PM ET)

Giants vs. Red Sox over 8.5 runs carries a 7.4% edge and a probability of 53.9% at +115 odds, according to our model.

Braves vs. Brewers Over 7.5 runs (-113)

• Edge: 6.8%
• Probability: 59.9%
• Matchup: Braves vs. Brewers (2:10PM ET)

Braves vs. Brewers Over 7.5 runs at -113 odds shows a 6.8% edge, supported by a 59.9% probability in simulations.

Reds vs. Diamondbacks over 7.5 runs (-117)

• Edge: 6.5%
• Probability: 60.4%
• Matchup: Reds vs. Diamondbacks (8:10PM ET)

A 6.5% edge and 60.4% probability make Reds vs. Diamondbacks over 7.5 runs a value play in the Reds vs. Diamondbacks matchup, per our model.

Giants ML (+190)

• Edge: 6.0%
• Probability: 40.4%
• Matchup: Giants vs. Red Sox (7:15PM ET)

Giants ML at +190 odds presents a 6.0% edge, with simulations resulting in a probability of 40.4%.

Angels vs. Rangers Over 8.5 runs (+108)

• Edge: 5.7%
• Probability: 53.7%
• Matchup: Angels vs. Rangers (7:05PM ET)

Our model finds value on Over 8.5 runs in Angels vs. Rangers at +108 odds, supported by an edge of 5.7%.

Athletics vs. Astros Over 7.5 runs (-113)

• Edge: 5.5%
• Probability: 58.5%
• Matchup: Athletics vs. Astros (7:10PM ET)

Our model has uncovered value on Athletics vs. Astros Over 7.5 runs at -113 odds. A 58.5% probability produces a 5.5% edge, making this a strong play for today's MLB action.

Rays vs. Orioles Over 7.5 runs (-115)

• Edge: 4.5%
• Probability: 58%
• Matchup: Rays vs. Orioles (7:05PM ET)

A 4.5% edge on a 58% probability makes Over 7.5 runs at -115 odds a solid value play in today's Rays vs. Orioles matchup.

Tigers vs. RoyalsOver 8.5 runs (-104)

• Edge: 4.0%
• Probability: 55%
• Matchup: Tigers vs. Royals (7:15PM ET)

Our model projects value on Over 8.5 runs at -104 odds. A 55% probability produces a 4.0% edge, making the Over the favorable side in today's matchup.

Giants +1.5 (-113)

• Edge: 3.8%
• Probability: 56.8%
• Matchup: Giants vs. Red Sox (7:15PM ET)

Rounding out our top 10 bets, Giants +1.5 at -113 odds shows a 56.8% probability and a 3.8% edge.

MLB best bets summary: Saturday, 8/22/2026

As of 4:06AM ET, here are our top MLB bets by edge recommended by our model:

List of upcoming MLB games to bet on [8/22/2026]

• Blue Jays vs. Yankees (1:35PM ET, Saturday)
• Braves vs. Brewers (2:10PM ET, Saturday)
• Nationals vs. Marlins (4:10PM ET, Saturday)
• Cardinals vs. Phillies (6:05PM ET, Saturday)
• Rays vs. Orioles (7:05PM ET, Saturday)
• Angels vs. Rangers (7:05PM ET, Saturday)
• Athletics vs. Astros (7:10PM ET, Saturday)
• Mets vs. White Sox (7:10PM ET, Saturday)
• Tigers vs. Royals (7:15PM ET, Saturday)
• Cubs vs. Mariners (7:15PM ET, Saturday)
• Giants vs. Red Sox (7:15PM ET, Saturday)
• Pirates vs. Dodgers (7:15PM ET, Saturday)
• Guardians vs. Rockies (8:10PM ET, Saturday)
• Reds vs. D-Backs (8:10PM ET, Saturday)
• Twins vs. Padres (8:40PM ET, Saturday)

Conclusion

Our MLB best bets are locked and loaded for August 22, 2026, featuring plays such as over 7 runs in the Blue Jays vs. Yankees matchup and over 8.5 runs in the Giants vs. Red Sox matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.