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Read Article MLB picks today: Saturday's MLB best bets highlight Twins vs. Padres play [8/22/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get MLB picks today and best bets for Saturday, August 22, 2026.
Today’s MLB picks for August 22, 2026 are here, with Twins vs. Padres among the top plays identified by our model across Saturday’s MLB schedule.
Dimers’ predictive analytics engine runs 24/7, scanning the latest baseball odds to unearth legitimate betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of MLB best bets tonight [8/22, updated 8:09PM ET]
Below, you’ll find today’s MLB best bets, ranked by edge for Saturday, August 22, 2026.
Twins vs. Padres Over 7.5 runs (-113)
- Edge: 3.6%
- Probability: 56.7%
- Matchup: Twins vs. Padres (8:40PM ET)
Our model has identified value on Over 7.5 runs in Twins vs. Padres at -113 odds. A 56.7% probability produces an edge of 3.6%, making this the strongest play for today's MLB slate.
MLB best bets summary: Saturday, 8/22/2026
As of 8:09PM ET, here is our top MLB bet by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Prob. |
|---|---|---|---|---|
| Twins vs. Padres | Over 7.5 runs | -113 @ Novig | 3.6% | 56.7% |
List of upcoming MLB games to bet on [8/22/2026]
- Guardians vs. Rockies (8:10PM ET, Saturday)
- Reds vs. D-Backs (8:10PM ET, Saturday)
- Twins vs. Padres (8:40PM ET, Saturday)
- Cardinals vs. Phillies (1:35PM ET, Sunday)
- Rays vs. Orioles (1:35PM ET, Sunday)
- Blue Jays vs. Yankees (1:35PM ET, Sunday)
- Nationals vs. Marlins (1:40PM ET, Sunday)
- Tigers vs. Royals (2:10PM ET, Sunday)
- Athletics vs. Astros (2:10PM ET, Sunday)
- Angels vs. Rangers (2:35PM ET, Sunday)
- Guardians vs. Rockies (3:10PM ET, Sunday)
- Giants vs. Red Sox (3:15PM ET, Sunday)
- Pirates vs. Dodgers (4:10PM ET, Sunday)
- Cubs vs. Mariners (4:10PM ET, Sunday)
- Twins vs. Padres (4:10PM ET, Sunday)
- Reds vs. D-Backs (4:15PM ET, Sunday)
- Braves vs. Brewers (7:10PM ET, Sunday)
Conclusion
Our MLB best bets are locked and loaded for August 22, 2026, featuring plays such as over 7.5 runs in the Twins vs. Padres matchup. Powered by advanced simulations, these picks are here to boost your betting game.
Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.
All odds and probabilities in this article are correct and accurate at the time of publication.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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